Detecting the Undetected: Heart Failure Screening at the Lymphoedema Point of Care

Conditions

• Heart Failure
• Heart Failure (HF)
• Heart Failure (for Example, Fluid Overload)
• Lymphedema
• Lymphedema, Lower Limb

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Study Details

Heart failure affects more people than the four most common cancers combined. When identified early, management is more straightforward, preventing complications, hospitalisations, and fatalities. Breathlessness and fatigue are cardinal symptoms of heart failure that can present in a number of conditions. As a result, leg swelling, the third cardinal symptom, is the first noted in many people. The presence of leg swelling leads to patients being seen in lymphoedema clinics before the need for cardiology investigation has been identified. Lymphoedema is the presence of chronic oedema as a result of congenital abnormalities, inflammation, infection, trauma, or cancer and its treatments. The vast majority of lymphoedema patients have swelling in their legs. A recent study has shown that 9.4% lymphoedema patients need to be investigated for heart failure. At present, the need for investigation is identified by performing a laboratory blood test, which takes time to arrange and complete. An alternate point of care test can provide a result in 12-minutes at the lymphoedema appointment, and enable appropriate action to be taken. This can reduce the demands on primary care and shorten the chain of events to a specialist assessment, as well as reducing inappropriate referrals. This research, funded by NHS Wales Performance and Improvement, will perform a point of care test to screen for possible heart failure in lymphoedema clinics and establish the clinical utility by exploring the experiences of patients and staff involved and determining the health economic benefits. A supplementary aim is to compare the point of care test to the currently used laboratory test in a subsample to promote confidence in the test and support efforts to spread and scale across all health boards in Wales on completion.

Key Dates

First listed

Mar 27, 2026

Start date

May 31, 2026

Status verified

Mar 2026

Primary completion

Oct 31, 2027

Completion

Sep 30, 2028

Study Design

Enrollment

618 participants (estimated)

Arms

• Arm: Bilateral lower limb lymphoedema patients
  People with bilateral lower limb lymphoedema who do not have a prior diagnosis of heart failure and have not been investigated for heart failure in the last 12-months, unless their oedema has increased in severity.

Primary Outcome Measure

Number of participants that need a heart failure investigation. [ Time Frame: Day 1. ]

Central Contacts

• National Lymphoedema Team
  +4401639862767
  [email protected]

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