Pain & Reward Neuromodulation of CNS Circuits

Sponsor
Duke University
Study ID
NCT07525063
Status
Not Yet Recruiting

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Conditions

  • Chronic Pain and Fatigue
  • Fibromyalgia
  • Fibromyalgia Syndrome

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation (TMS) — DEVICE
    TMS protocol delivered via MagPro X100 stimulator with figure-8 coil targeting prefrontal cortex.

Study Details

This pilot feasibility study aims to evaluate transcranial magnetic stimulation (TMS) targeting the prefrontal cortex in patients with fibromyalgia syndrome (FMS). The study will assess preliminary efficacy and mechanisms of central nervous system changes using neuroimaging, behavioral tasks, sensory testing, and neuroimmune markers. Participants will undergo MRI scans, multi-day TMS sessions, and complete questionnaires. The goal is to generate pilot data for future trials on neuromodulation for chronic pain.

Key Dates

First listed
Apr 13, 2026
Start date
Jul 31, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Active TMS
    Participants receive TMS over 4 consecutive days (20 sessions total).

Primary Outcome Measure

Change in Pain Intensity [ Time Frame: Baseline MRI and post-intervention MRI (approximately 3 weeks) ]

Central Contacts

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