Pain & Reward Neuromodulation of CNS Circuits

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT07525063
Status
Enrolling By Invitation

Conditions

  • Chronic Pain and Fatigue
  • Fibromyalgia
  • Fibromyalgia Syndrome

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation (TMS) — DEVICE
    TMS protocol delivered via MagPro X100 stimulator with figure-8 coil targeting prefrontal cortex.

Study Details

This pilot feasibility study aims to evaluate transcranial magnetic stimulation (TMS) targeting the prefrontal cortex in patients with fibromyalgia syndrome (FMS). The study will assess preliminary efficacy and mechanisms of central nervous system changes using neuroimaging, behavioral tasks, sensory testing, and neuroimmune markers. Participants will undergo MRI scans, multi-day TMS sessions, and complete questionnaires. The goal is to generate pilot data for future trials on neuromodulation for chronic pain.

Key Dates

First listed
Apr 13, 2026
Start date
Jul 21, 2026
Status verified
Jul 2026
Primary completion
Dec 31, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Active TMS
    Participants receive TMS over 4 consecutive days (20 sessions total).

Primary Outcome Measure

Change in Pain Intensity [ Time Frame: Baseline MRI and post-intervention MRI (approximately 3 weeks) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27710-

Find similar trials in Durham, NC

By research site
Duke University Medical Center· Durham, NC

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