Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada

Sponsor
University of British Columbia
Study ID
NCT07536178
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
19 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Woodsmoke (Lodgepole Pine) exposure — OTHER
    Woodsmoke will be freshly generated using a furnace tube burning dried, ground lodgepole pine (Pinus contorta) to achieve the nominal PM2.5 (particulate matter with an aerodynamic diameter of less than or equal to 2.5 micrometres) concentrations specified for each study arm.
  • Filtered air exposure — OTHER
    Exposures to HEPA filtered air, as a control.

Study Details

Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated exposure contributes to long-term lung disease. This study is a controlled human exposure to varying concentrations of WFS in a safe setting. By comparing the effects of different concentrations, this research will improve understanding of health impacts, identify who may be most vulnerable to exposures, and explore biological changes that could lead to chronic illness.

Key Dates

First listed
Apr 17, 2026
Start date
Apr 1, 2026
Status verified
Apr 2026
Primary completion
Aug 31, 2029
Completion
Aug 31, 2030

Study Design

Enrollment
24 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: Arm A) Three repeated exposures to a low air pollution concentration
    Three consecutive days with a 2-hour woodsmoke exposure at 35 µg/m3 of PM2.5 each day.
  • Experimental: Arm B) Three repeated exposures to a moderate air pollution concentration
    Three consecutive days with a 2-hour woodsmoke exposure at 105 µg/m3 of PM2.5 each day.
  • Experimental: Arm C) Single exposure to a higher air pollution concentration
    Two consecutive days of 2-hour filtered air exposures, followed by 1 day with a 2-hour woodsmoke exposure at 315 µg/m3 of PM2.5.

Primary Outcome Measure

Effects of PM2.5 exposures and concentration on exhaled nitric oxide. [ Time Frame: Comparison of the different arms over the span of 4 months. ]

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