The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity

Sponsor
Claus Bogh Juhl
Study ID
NCT07542327
Status
Not Yet Recruiting

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Conditions

  • Obesity
  • Obesity & Overweight
  • Obesity Type 2 Diabetes Mellitus
  • Obesity and Obesity-related Medical Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Study Details

The purpose of this study is to explore if GPCR-autoantibodies: 1. are pressent in people living with obesity, and are associated with degree of obesity 2. if it is associated with obesity related diseases

Key Dates

First listed
Apr 21, 2026
Start date
Sep 1, 2026
Status verified
Apr 2026
Primary completion
Sep 1, 2027
Completion
Sep 1, 2027

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: The South Danish Obesity Initiative (SDOI)
    The project will take advantage of the South Danish Obesity Initiative (SDOI) cohort. This is an ongoing clinical initiative, offering screening of a broad panel of obesity related diseases to individuals with BMI above 30 kg/m² and age between 18 and 60 years. People are referred from their general practitioners or from hospital departments and undergo screening for diabetes, dyslipidemia, obstructive sleep apnea, metabolic-associated steatohepatitis and hypertension. In addition, the participants answer questionnaires. A cohort of people with BMI 18.5 to 30 kg/m² has been assessed with an identical screening program with the purpose of serving as a control group. Only participants who gave informed consent to use their data for research purposes are included in this study. The study protocol and initial results have previously been published (Juhl C.B, et al 2024.DOI: 10.2147/DMSO.S456028).

Primary Outcome Measure

Exploring the pressence and role of GPCR-autoantibodies in obesity [ Time Frame: At the time of enrolement ]

Central Contacts

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