Obesity / overweight Clinical Trials

Recruiting obesity / overweight studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat obesity / overweight. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting obesity / overweight studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting obesity / overweight trials

Within

Adiposity Distribution in Acute Respiratory Failure

for Acute Hypoxemic Respiratory Failure

1 site in Boston

Sponsor: Maurizio F. Cereda, MD

Sex: All·Age: 18 - 80

Code: NCT07019987

Simplifying Diet Tracking in a Digital Weight Loss Intervention

for Overweight

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07601061

Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose

for Nutrition, Healthy

1 site in Athens

Sponsor: University of Georgia

Sex: All·Age: 25 - 75·Accepts healthy volunteers

Code: NCT07696403

Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

for Obesity & Overweight

Sponsor: Knut Mai

Sex: All·Age: 18 - 70

Code: NCT07711548

Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults

for Obesity & Overweight

Sponsor: Lumos Pharma

Sex: All·Age: 60 - 84

Code: NCT07754045·Phase 2

SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer

for Endometrial Cancer

Sponsor: Hospital Universitari de Bellvitge

Sex: Female·Age: 18+

Code: NCT07462663·Phase 4

Nutrition Intervention Optimization to Better Utilize Resources and Support Health

for Diabete Type 2

1 site in Dallas

Sponsor: Tufts University

Sex: All·Age: 18+

Code: NCT07713836

Chrono-Fasting in Overweight and Obese Adolescents

for Obesity

Sponsor: University of Thessaly

Sex: All·Age: 12 - 18

Code: NCT07759414

AMAZE 13: A Research Study Investigating How Well the Medicine Zenagamtide Helps People in Asia With Excess Body Weight Lose Weight

for Obesity

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07668401·Phase 3

Target Physiotherapy Versus Exercise Support Intervention for Bladder-bowel Dysfunction in Adolescents With Obesity

for Bladder-Bowel Dysfunction

Sponsor: University of Lisbon

Sex: All·Age: 13 - 18

Code: NCT07724158

Human Models of Selective Insulin Resistance: Pancreatic Clamp

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06558422·Phase 1

Digitally Enhanced Cognitive-Behavioral Therapy

for Depression in Adolescence

1 site in Aurora

Sponsor: Colorado State University

Sex: All·Age: 12 - 17

Code: NCT07569991

GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry

for Heart Failure With Preserved Ejection Fraction

Sponsor: Miedziowe Centrum Zdrowia SA

Sex: All·Age: 18+

Code: NCT07787936

Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity

for Type 1 Diabetes Mellitus

Sponsor: Royal North Shore Hospital

Sex: All·Age: 18 - 70

Code: NCT06180616·Phase 2

A Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health Problems

for Obesity

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07790861·Phase 3

Effect of a Mobile App for Obese Children on Eating Attitudes, Eating Awareness, and Healthy Eating Self-Efficacy

for Obesity

Sponsor: Cumhuriyet University

Sex: All·Age: 8 - 10

Code: NCT07289425

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway

for Cardiovascular Diseases

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06320951·Phase 2

HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide

for Type 2 Diabetes Mellitus (T2DM)

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 65 - 85

Code: NCT07760948·Phase 2

Obesity and Oral Diseases in Adult Patients

for Obesity

Sponsor: University of Bergen

Sex: All·Age: 20 - 70

Code: NCT04602572

Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

for Weight Loss

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07535892

Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals

for Obesity

Sponsor: Acibadem University

Sex: All·Age: 18 - 65

Code: NCT07609160

Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy Discontinuation

for Obesity

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT07729332·Phase 4

Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer

for Obesity

Sponsor: Tongji Hospital

Sex: Female·Age: 18 - 45

Code: NCT07781150·Phase 2

Digital Resistance Training for Midlife Women Using GLP-1

for Women's Health

1 site in Baton Rouge

Sponsor: Louisiana State University and A&M College

Sex: Female·Age: 40 - 59

Code: NCT07787533

Incisionless Suture Plications in a POSE2.0 Obesity Study

for Obesity

Sponsor: USGI Medical

Sex: All·Age: 22 - 65

Code: NCT06272201

Inhaled Nitric Oxide in Severe Obesity

for Obesity

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06675435

Vibegron for ENergy Thinking and Resilience in Aging

for Obesity

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 45 - 75

Code: NCT06987383·Phase 3

PLAY2CONTROL Study

for Type 2 Diabetes

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 5 - 21

Code: NCT07556679

Blood-based sEV Proteins for Early Detection of 2 Diabetes

for Obesity & Overweight

Sponsor: Hong Kong Baptist University

Sex: All·Age: 40 - 59·Accepts healthy volunteers

Code: NCT07728591

A Study of Macupatide (LY3532226) in Participants With Obesity or Overweight Without Type 2 Diabetes

for Obesity

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07765511·Phase 1

Polydextrose Functional Gummies for Weight Management in Adults With Overweight or Obesity

for Obesity & Overweight

Sponsor: Nutris We Care About You S.L.

Sex: All·Age: 18 - 70

Code: NCT07758387

Comparison of Day Hospitalization Versus Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity

for Severe Adolescent Obesity

Sponsor: Fondation Santé des Étudiants de France

Sex: All·Age: 12 - 20

Code: NCT07652190

Study Evaluating the Safety and Feasibility of Endoscopic Duodenal Injections of Autologous Mesenchymal Stem Cells

for Diabete Type 2

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT07344324

GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward

for Obesity, Childhood

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 12 - 18

Code: NCT06977438·Phase 4

Enhancing Mental and Physical Health of Women Veterans 3.0

for Cardiovascular Diseases

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07356479

"Effectiveness of Supervised and Unsupervised mHealth-based Exercise Interventions on Clinical Outcomes in Adults With Type 2 Diabetes and Obesity Within a Primary Care Context"

for Diabetes Mellitus, Type 2

Sponsor: Escuela Universitaria de Osuna

Sex: All·Age: 30 - 65

Code: NCT07685080

Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, and Cognition in Post-Menopausal Women

for Obesity & Overweight

1 site in Little Rock

Sponsor: University of Arkansas

Sex: Female·Age: 50 - 65·Accepts healthy volunteers

Code: NCT07705724

Qing-Xin-Jiao-Tai Decoction for Insomnia Comorbid With Obesity Presenting With Heart-Kidney Non-interaction Syndrome

for Insomnia

Sponsor: Fohow Pharmaceutical Group

Sex: All·Age: 18 - 65

Code: NCT07754383·EARLY_Phase 1

GLP-1s in Hip and Knee Arthroplasty

for Arthritis

Sponsor: Nova Scotia Health Authority

Sex: All·Age: 18 - 90

Code: NCT07755085·Phase 4

Metabolic Flux Analysis in Metabolic Dysfunction-Associated Steatotic Liver Disease

for Metabolic Dysfunction-Associated Steatotic Liver Disease

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 21 - 70

Code: NCT07760909

Treating Binge Eating and Obesity Digitally in Women

for Binge Eating

1 site in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05693896

Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss

for Obesity

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06299644

Reset: Enhancing Weight Loss in a Digital Intervention

for Obesity

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07032571

COMPASS 65+ - Community-based Physical Activity Snacks for Healthy Aging in Overweight and Obese Aged Adults

for Obesity & Overweight

Sponsor: University of Coimbra

Sex: All·Age: 65+

Code: NCT07289529

Optimizing Adaptive Intensive Behavioral Therapy for Obesity During the Transition to Older Adulthood

for Obesity & Overweight

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 50 - 75

Code: NCT07446907

Disulfiram in Rheumatoid Arthritis

for Rheumatoid Arthritis

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 75

Code: NCT07534332·Phase 2

Ultrasound Assessment of Tongue Characteristics in Adolescents With Obesity and Obstructive Sleep Disorders

for Obesity & Overweight Sleep

Sponsor: Vrije Universiteit Brussel

Sex: All·Age: 12 - 18·Accepts healthy volunteers

Code: NCT07613944

BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity

for Obesity & Overweight

Sponsor: Carnot Laboratories

Sex: All·Age: 18+

Code: NCT07622810·Phase 3

Dance-Based Exercise Versus Clinical Pilates in Women With Overweight or Obesity

for Overweight

Sponsor: Pamukkale University

Sex: Female·Age: 18 - 60

Code: NCT07745166

Motivational Interviewing for Overweight and Obese Adults at Healthy Life Centers

for Overweight

Sponsor: Sakarya University

Sex: All·Age: 18+

Code: NCT07745231

Motivational Interviews Based on the Five-Step (5A) Model on Obesity Risk

for Obesity & Overweight

Sponsor: Istinye University

Sex: All·Age: 18 - 64

Code: NCT07769736

Acupoint Catgut Embedding With Laser Acupuncture for Weight Loss in Adults With Obesity

for Obesity

Sponsor: Taipei City Hospital

Sex: All·Age: 20 - 65

Code: NCT07770893

A Study of SYH2092 Injection in Healthy Participants

for Overweight or Obesity

Sponsor: CSPC Megalith Biopharmaceutical Co.,Ltd.

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07776041·Phase 1

A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

for Atherosclerosis

31 sites incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07783802·Phase 2

Weight and Metabolic Management Study

for Overweight

Sponsor: Elenzia

Sex: All·Age: 25 - 65

Code: NCT07789223

ENLIGHT Trial: ESG With Fundal Mucosal Ablation

for Obesity

1 site in Morgantown

Sponsor: West Virginia University

Sex: All·Age: 18+

Code: NCT07792226

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

for Overweight

79 sites incl. Anniston

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07794579·Phase 3

Vitis Intervention Trial in Substrate Metabolism

for Obesity & Overweight

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 25 - 60·Accepts healthy volunteers

Code: NCT07800988

A Study to Learn About Safety and Effects of Once-weekly Treatment With Berobenatide in Adults With Obesity Disease in Japan (VESPER-JW)

for Obesity

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07794761·Phase 3

A Study to Learn About Safety and Effects of Once-monthly Treatment With Berobenatide in Adults With Obesity Disease in Japan (VESPER-JM)

for Obesity

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07794774·Phase 3

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Obesity / overweight clinical trials — common questions

Are obesity / overweight clinical trials free to join?

Yes. Participating in a obesity / overweight clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a obesity / overweight clinical trial?

Each obesity / overweight study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a obesity / overweight trial near me?

Use the location controls above. We'll show recruiting obesity / overweight trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many obesity / overweight trials are recruiting right now?

We're currently tracking roughly 565 recruiting obesity / overweight trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Obesity / overweight trials by city

Boston, MA Birmingham, AL Los Angeles, CA Aurora, CO Chicago, IL Miami, FL Ann Arbor, MI Salt Lake City, UT San Diego, CA Tallahassee, FL Cincinnati, OH Cleveland, OH

Related specialties

Endocrinology Metabolic health Weight loss