Validation Study of the ExéSem Battery Designed to Differentiate the Contribution of Executive Functions in Semantic Disorders

Sponsor
Hospices Civils de Lyon
Study ID
NCT07573046
Status
Not Yet Recruiting

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Conditions

  • Alzheimer's Disease
  • People Without Neurocognitive Disorder
  • Progressive Primary Aphasia Semantic Variant
  • Vascular Neurocognitive Disorder

Eligibility Criteria

Sex
ALL
Age
50 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • ExéSem cognitive battery — DIAGNOSTIC_TEST
    The ExéSem battery is a neuropsychological assessment tool designed to evaluate semantic processing and the contribution of executive control in patients with or without neurocognitive disorders. It consists of three tasks: (1) a dual task combining semantic judgment and semantic matching using identical items, (2) a word-to-picture matching task, and (3) a rapid naming task. Each task is structured to manipulate the level of executive demand required to access semantic representations. This variation allows the identification of whether semantic difficulties remain stable or worsen under increased executive load, thereby distinguishing primary semantic deficits from executive-related semantic impairments. The battery is administered by a trained professional using standardized instructions and requires approximately 30 minutes to complete. It is used for diagnostic and research purposes only and does not involve any therapeutic intervention.

Study Details

This protocol describes a study aimed at evaluating the psychometric properties of the ExéSem battery, developed to differentiate semantic deficits from executive semantic impairments in patients with post-lesional or neurodegenerative anomia. Currently available tools do not allow a straightforward distinction between these deficits, limiting diagnostic accuracy and clinical management. The ExéSem battery was developed through a collaboration between Hospices Civils de Lyon, the University of Mons, and Laval University to address this gap. The battery includes three main tasks: (1) a dual task combining semantic judgment and semantic matching using identical items, (2) a word-picture matching task, and (3) a rapid naming task. Each task is designed to manipulate the level of executive control required to access semantic representations. This allows the identification of whether performance declines under increased executive demand, thereby distinguishing executive-related semantic impairments.

Key Dates

First listed
May 7, 2026
Start date
Sep 9, 2026
Status verified
May 2026
Primary completion
Aug 31, 2029
Completion
Sep 9, 2029

Study Design

Enrollment
140 participants (estimated)

Arms

  • Arm: Participants without cognitive impairment
    Participanst with a MoCA score greater than or equal to 26/30 and a score greater than the alert threshold based on age and education level on the DTLA scale. Participants who have never received a diagnosis of cognitive impairment.
  • Arm: Participants with Cognitive Impairment
    Participants receiving memory clinic care with a diagnosis of Alzheimer's disease, at the stage of minor or major neurocognitive impairment, according to the 2011 NIA-AA criteria, or with a diagnosis of vascular neurocognitive impairment according to the VasCog-2-WSO diagnostic criteria , or with a diagnosis of primary progressive aphasia with semantic variant. Participants with a Mini-Mental State Examination (MMSE) score ≥ 20/30, within the 6 months preceding enrollment;

Primary Outcome Measure

Score obtained on the ExéSem battery [ Time Frame: At enrollment ]

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