Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

Part of paid clinical trials in Huntsville, Alabama.

Sponsor
Rapport Therapeutics Inc.
Study ID
NCT07594119
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • RAP-219 — DRUG
    RAP-219 medium dose tablets administered orally daily
  • RAP-219 — DRUG
    RAP-219 low dose tablets administered orally daily
  • Placebo — OTHER
    Matching placebo tablets administered orally

Study Details

This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in reducing focal seizure frequency.

Key Dates

First listed
May 18, 2026
Start date
Sep 30, 2026
Status verified
Aug 2026
Primary completion
Jul 31, 2029
Completion
Sep 30, 2029

Study Design

Enrollment
312 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Active Arm- Medium Dose
    RAP-219 daily tablets administered orally
  • Experimental: Active Arm-Low Dose
    RAP-219 daily tablets administered orally
  • Placebo Comparator: Placebo
    Inert comparator matching the active treatment

Primary Outcome Measure

Median Percent Change in Seizure Frequency [ Time Frame: End of double-blind treatment period (end of week 14) vs Baseline ]

Central Contacts

Locations (11)

FacilityCityStateZIPSite coordinators
Clinic for NeurologyHuntsvilleAlabama35801-
Pillar Clinical ResearchBentonvilleArkansas72712-
Colorado Springs Neurological AssociatesColorado SpringsColorado80919-
K2 Medical ResearchMaitlandFlorida32751-
Serenity Research Center, LLCMiamiFlorida33176-
Re:Cognition Health-ChicagoChicagoIllinois60611-
Lenox Hill HospitalNew YorkNew York10075-
Velocity Clinical ResearchRaleighNorth Carolina27607-
Vanderbilt University Medical CenterNashvilleTennessee37179-
Baylor College of MedicineHoustonTexas77030-
University of Texas Health Science Center in HoustonHoustonTexas77030-

Find similar trials in Huntsville, AL

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By condition
Epilepsy
By specialty
NeurologyBrain disorders
By research site
Clinic for Neurology· Huntsville, ALPillar Clinical Research· Bentonville, ARColorado Springs Neurological Associates· Colorado Springs, COK2 Medical Research· Maitland, FLSerenity Research Center, LLC· Miami, FLRe:Cognition Health-Chicago· Chicago, IL

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