Investigating Central Contributions to Fatigue Using Non-invasive Brain Stimulation

Sponsor
Vrije Universiteit Brussel
Study ID
NCT07613970
Phase
PHASE1/PHASE2
Status
Not Yet Recruiting

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Conditions

  • Cerebrovascular Accident (CVA)
  • Hemorrhage Stroke
  • Ischemia Stroke
  • Stroke

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Transcranial alternating current stimulation (tACS) — DEVICE
    Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that uses electrodes on the scalp to apply weak alternating electrical currents to the brain.
  • Sham treatment — DEVICE
    mimics active tACS but stops after 1 minute

Study Details

The goal of this interventional study is to understand the contribution of the central components to the manifestation of neuromuscular fatigue in stroke survivors. The study will include adults with a first-ever stroke in the subacute phase. The main question it aims to answer: • How does the brain activity contribute to the manifestation of neuromuscular fatigue in stroke survivors? Researchers will compare stroke participants receiving active vs sham tACS in a single session before the fatiguing contractions to determine whether central changes can influence fatigue onset/progression. Participants will: * Perform repeated leg muscle contractions until fatigue while seated in an experimental setup * Receive either active or sham tACS for 20 minutes before the fatiguing contractions. * Wear non-invasive sensors to record brain activity (EEG) and muscle activity (EMG) during the task * Complete the study during a single experimental session in which fatigue-related changes will be measured throughout the task

Key Dates

First listed
May 29, 2026
Start date
Sep 1, 2026
Status verified
May 2026
Primary completion
Oct 31, 2029
Completion
Oct 31, 2029

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Active tACS
  • Sham Comparator: Sham tACS

Primary Outcome Measure

Absolute and relative spectral power and ERD/ERS magnitude [ Time Frame: Outcome measure will be recorded at baseline and throughout the fatiguing contractions in the single experimental session (up to 40 minutes) and compared over 4 fatigue phases. ]

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