Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position

Conditions

• Atelectases, Postoperative Pulmonary
• Atelectasis
• Cardiac Output
• Cardiac Surgery
• Cardiac Surgery Recovery
• Cardiopulmonary Bypass
• Heart Failure
• Prone Position
• Pulmonary Arterial Pressure
• Recruitment Maneuver
• Respiratory Mechanics
• Right Ventricular Function
• Vasoconstriction

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Prone position — PROCEDURE
  Prone position is applied in the intervention group immediately after randomization, patients will be prone for a total of 2 hours and 15 minutes. During this time 3 data collection points occur (t1, t2 \& t3).

Study Details

Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle. Recruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF. Prone position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR. The investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.

Key Dates

First listed

Jun 8, 2026

Start date

Sep 30, 2026

Status verified

Jun 2026

Primary completion

May 31, 2028

Completion

Oct 31, 2028

Study Design

Enrollment

80 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• No Intervention: Supine position
  Control group. Will remain in supine position for the whole protocol.
• Experimental: Prone position
  Will be turned to prone position after baseline data collection (0) and return to supine position before the final data collection (t4).

Primary Outcome Measure

Cardiac Index [ Time Frame: 1 hour after baseline ]

Central Contacts

• Viktor Erbring, MD
  +46706456664
  [email protected]
• Per Persson, MD, PhD
  +46736467042
  [email protected]

Find similar trials

Related Studies

• Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
  Recruiting · Medtronic · Birmingham, Alabama
• Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
  Recruiting · UConn Health · Farmington, Connecticut
• Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
  Recruiting · Brigham and Women's Hospital · Dallas, Texas
• Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
  Recruiting · Arunark Kolipaka · Columbus, Ohio