Hearts on Fire: Targeting Inflammation in Heart Failure With Preserved Ejection Fraction

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT07634640
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Heart Failure With Preserved Ejection Fraction (HFPEF)

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Ferumoxytol infusion — DRUG
    Ferumoxytol infusion followed by cardiac MRI

Study Details

Subjects undergo a gadolinium-based CMR followed by an iron infusion and then a repeat CMR in 72 hours

Key Dates

Start date
Nov 3, 2023
Status verified
May 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
70 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Single arm study of subjects with HFpEF
    Subjects with HFpEF undergo a baseline gadolinium based cardiac MRI and the same day they undergo an iron infusion. Three days later they return for a follow-up cardiac MRI and the iron that has been administered 72 hours ago serves as the contrast media

Primary Outcome Measure

detection of inflammation [ Time Frame: 72 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32608
Ellen C Keeley, MD, MS
[email protected]
800-265-0820

Find similar trials in Gainesville, FL

By research site
University of Florida· Gainesville, FL

Related Studies