BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT07636213
Status
Not Yet Recruiting

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Conditions

  • Brain Injuries, Acute
  • Brain Trauma
  • Penetrating Head Injury
  • Traumatic Brain Injury

Eligibility Criteria

Sex
ALL
Age
16 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Blood Sample Collection — OTHER
    Subjects with confirmed Penetrating Brain Injury (PBI) will be enrolled upon arrival to each site and have blood samples collected at five timepoints by nurses/phlebotomists/approved research personnel. As soon as possible after injury, preferably within 4 hours of injury, but must be obtained within 8 hours of injury.

Study Details

The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago). Biospecimens will undergo biomarker analysis - biomarker data specific to PBI is extremely limited, and could provide critical insight to outcome identification and clinical decision making. This data will be used to build the first comprehensive PBI Data Commons, biorepository, and imaging repository which will create the infrastructure necessary to close critical knowledge gaps, advance biomarker discovery specific to PBI, and provide the foundation for future research aimed at improving prognostication and treatment for patients with this devastating injury.

Key Dates

Start date
Jul 1, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2035
Completion
Dec 31, 2035

Study Design

Enrollment
270 participants (estimated)

Primary Outcome Measure

Building the first PBI Data Commons, Biorepository, and Imaging Repository [ Time Frame: 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of ChicagoChicagoIllinois60637
Hugh Flynn
[email protected]
773-834-9627
Hugh Flynn
[email protected]
Susan Rowell, MD (PRINCIPAL_INVESTIGATOR)

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By research site
The University of Chicago· Chicago, IL

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