Trial in HPV Prevention for the U.S. Vietnamese Community

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT07637630
Status
Recruiting
Apply to this trial

Conditions

  • HPV Vaccination
  • HPV-related Cancers

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Expert Video — BEHAVIORAL
    Participants will watch a video featuring Vietnamese healthcare providers. In the video, the providers will endorse vaccine safety and efficacy, dispel common misconceptions or concerns, and use verbal persuasion techniques to recommend HPV vaccination.
  • Self-persuasion — BEHAVIORAL
    Participants will complete an interactive web-based task where they audio record reasons, summarized in their own words, for getting their adolescent the HPV vaccine.
  • Narrative Storytelling — BEHAVIORAL
    Participants will watch a video featuring U.S. Vietnamese parents. In the video, featured parents will describe stories of their experiences learning about the HPV vaccine as well as motivations to initiate and complete the vaccine series on-time for their adolescents.
  • Motivational Interviewing — BEHAVIORAL
    Participants will receive 2 calls (phone or Zoom) from a trained U.S. Vietnamese health educator. The health educator will use motivation interviewing (e.g., open-ended questions, acknowledging feelings, affirmations, reflective listening) to increase opportunities for and commitment to HPV vaccination while decreasing barriers (e.g., safety or access concerns).
  • Constant Component — BEHAVIORAL
    Each participant will receive the constant component through the study website, which includes a vaccine information statement from the CDC with details on HPV vaccine benefits, potential side effects, and recommended vaccination schedule, as well as online information on access and locations for HPV vaccine (e.g., list of Vaccines for Children providers where Medicaid, uninsured, or underinsured adolescents can be vaccinated for free).

Study Details

The purpose of the HERO study is to leverage the Multiphase Optimization Strategy (MOST) framework to conduct a pilot trial testing four different intervention components (expert video, self-persuasion, narrative storytelling, and motivational interviewing) targeting HPV vaccination among U.S. Vietnamese. PRIMARY AIM To assess the feasibility and acceptability of each of the four digital HERO intervention components in a pilot optimization trial using the MOST framework. Using a highly efficient design, the study team will randomize 96 Vietnamese parents of unvaccinated adolescents to receive 0 to 4 HERO components. The study team will establish the feasibility (reach, retention, adherence) and acceptability (usability, satisfaction, usefulness, cultural relevance) of each component (expert video, self-persuasion, narrative storytelling, and motivational interviewing). SECONDARY AIM To investigate effects of each component on HPV vaccination outcomes and psychosocial mediators. The study team will examine the effects on HPV vaccination (initiation and intention) and psychosocial mediators.

Key Dates

Start date
May 1, 2026
Status verified
Jun 2026
Primary completion
Jun 30, 2029
Completion
Jun 30, 2029

Study Design

Enrollment
96 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Experimental: Exp Condition 1
    Research participant receives the Constant component + Expert video + Self-persuasion + Narrative storytelling + Motivational interviewing
  • Experimental: Experimental: Exp Condition 2
    Research participant receives Constant + Expert video + Self-persuasion + Narrative storytelling.
  • Experimental: Experimental: Exp Condition 3
    Research participant receives Constant + Expert video + Self-persuasion + Motivational interviewing
  • Experimental: Experimental: Exp Condition 4
    Research participant receives Constant + Expert video + Self-persuasion
  • Experimental: Experimental: Exp Condition 5
    Research participant receives Constant + Expert video + Narrative storytelling + Motivational interviewing
  • Experimental: Experimental: Exp Condition 6
    Research participant receives Constant + Expert video + Narrative storytelling
  • Experimental: Experimental: Exp Condition 7
    Research participant receives Constant + Expert video + Motivational interviewing
  • Experimental: Experimental: Exp Condition 8
    Research participant receives Constant + Expert video
  • Experimental: Experimental: Exp Condition 9
    Research participant receives Constant + Self-persuasion + Narrative storytelling + Motivational interviewing
  • Experimental: Experimental: Exp Condition 10
    Research participant receives Constant + Self-persuasion + Narrative storytelling
  • Experimental: Experimental: Exp Condition 11
    Research participant receives Constant + Self-persuasion + Motivational interviewing
  • Experimental: Experimental: Exp Condition 12
    Research participant receives Constant + Self-persuasion
  • Experimental: Experimental: Exp Condition 13
    Research participant receives Constant + Narrative storytelling + Motivational interviewing
  • Experimental: Experimental: Exp Condition 14
    Research participant receives Constant + Narrative storytelling
  • Experimental: Experimental: Exp Condition 15
    Research participant receives Constant + Motivational interviewing
  • Experimental: Experimental: Exp Condition 16
    Research participant receives the Constant component only

Primary Outcome Measure

Feasibility: Reach [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Northwestern UniversityChicagoIllinois60611
Milkie Vu
[email protected]
312-503-6592
Ninh Nguyen
[email protected]

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