CBD Knee Osteoarthritis Study

Conditions

• Osteoarthitis

Eligibility Criteria

Sex

ALL

Age

21 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Cannabidiol (CBD) — DIETARY_SUPPLEMENT
  250 mg of CBD will be dissolved in 1 ml of Castor Oil. Participants will use 1ml of this solution on each knee BID
• Castor Oil (Placebo) — OTHER
  1 ml of Castor oil alone will be applied to each knee BID as the placebo

Study Details

Osteoarthritis of the knee is a common cause of pain in the US. The currently available medicines for knee osteoarthritis sometimes are not effective at relieving the pain or have unacceptable side effects. Thus, alternate pain relieving treatments are needed. CBD, an active chemical from the hemp derived cannabis sativa plant, has received a lot of attention for its potential pain relieving properties, but there has been limited research to find out if topically applied CBD can decrease pain from knee osteoarthritis. CBD lacks the psychoactive effects seen with marijuana use, because it does not contain THC which is responsible for those effects in marijuana. It is legal to use CBD in the State of Tennessee (site of study). The CBD Knee Study is sponsored by the University of Tennessee Health Science Center and is a collaborative effort between doctors at UT and Campbell Clinic. In the CBD Knee Study, the investigators are examining whether topically applied CBD dissolved in Castor Oil will relieve knee pain in persons with knee osteoarthritis. Persons who take part in the study would need to come for study visits, fill out questionnaires about their health and knee pain, and would be asked to use the topical study oil on their knees. Taking part in the CBD Knee Study is voluntary.

Key Dates

Start date

Jul 1, 2026

Status verified

Apr 2026

Primary completion

Mar 20, 2028

Completion

Mar 30, 2028

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Arms

• Active Comparator: CBD+Castol Oil
  250 mg CBD dissolved in 1 ml of Castor Oil to be applied topically to the knee BID
• Placebo Comparator: Castor Oil Alone
  1 ml of Castor Oil Alone applied topically to the knee as the placebo comparator BID

Primary Outcome Measure

Knee Pain [ Time Frame: Day 1 - Baseline One Visit, Day 30 - Follow-up One Visit, Day 44 - Baseline Two Visit, and Day 74 - Follow-up Two Visit ]

Central Contacts

• Karen Derefinko, PhD
  901-448-5900
  [email protected]
• William Mihalko, MD, PhD
  901-448-2666
  [email protected]

Locations (1)

Find similar trials in Memphis, TN