Sacituzumab Tirumotecan in Pts w/ NEPC After Progression on Prior Chemotherapy

Part of paid clinical trials in Richmond, Virginia.

Sponsor
Virginia Commonwealth University
Study ID
NCT07639086
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Sacituzumab Tirumotecan — DRUG
    Sacituzumab tirumotecan will be administered by intravenous (IV) infusion on Days 1, 15, and 29 of each 42-day cycle until disease progression or criteria of disease progression met

Study Details

This is a phase 2, open-label, single-arm study of sacituzumab tirumotecan in neuroendocrine prostate cancer (NEPC) with progression after platinum-based chemotherapy.

Key Dates

Start date
Aug 31, 2026
Status verified
Jun 2026
Primary completion
Mar 31, 2030
Completion
Mar 31, 2032

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Sacituzumab Tirumotecan
    Sacituzumab tirumotecan 4mg/kg Intravenous infusion

Primary Outcome Measure

Evaluate the objective response rate (ORR) of sacituzumab tirumotecan in NEPC per Prostate Cancer Working Group (PCWG) modified Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST 1.1) [ Time Frame: Baseline, End of treatment, up to 30 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Virginia Commonwealth UniversityRichmondVirginia23298
Massey CTO GU Team
[email protected]
804-628-6430
Asit Paul, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Richmond, VA

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
Virginia Commonwealth University· Richmond, VA

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