Lattice Radiotherapy for Adults With Large Tumors

Conditions

• Large Tumor
• Palliative Radiotherapy

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Lattice Radiation Therapy (LRT) — RADIATION
  Lattice Radiation Therapy (LRT) is a specialized form of Intensity-Modulated Radiation Therapy (IMRT) designed to provide focused radiation to the deepest part of large tumors.

Study Details

The purpose of this study is to ask whether using a specialized radiation therapy technique called Lattice Radiation Therapy (LRT) can shrink large tumors when given with palliative radiation therapy. The primary questions are: * if LRT is safe and does not worsen existing side effects or cause new side effects * if adding LRT to standard radiation therapy can improve tumor shrinkage. Participants will have one additional radiation treatment (LRT) prior to starting palliative radiation and then their progress will be followed for one year.

Key Dates

Start date

Aug 1, 2026

Status verified

Jun 2026

Primary completion

Nov 30, 2029

Completion

Aug 31, 2030

Study Design

Enrollment

25 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Experimental: Lattice Radiation Therapy (LRT)
  Participants will receive one additional dose of Intensity-Modulated Radiation Therapy (IMRT) called Lattice Radiation Therapy (LRT) prior to starting regular palliative radiation therapy.

Primary Outcome Measure

Incidence of Radiotherapy (RT) treatment-related, non-hematologic CTCAE v6.0 Grade ≥ 3 toxicity and Adverse Events of Special Interest (AESI) at 90 days [ Time Frame: 90 days ]

Central Contacts

• Heather Franklin, RN BSN OCN
  919-668-3726
  [email protected]

Locations (1)

Find similar trials in Durham, NC

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