Evaluation of Serum IL-41 Level in Patients With Ankylosing Spondylitis and Psoriatic Arthritis

Sponsor
Assiut University
Study ID
NCT07648836
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • IL 41 — DIAGNOSTIC_TEST
    Serum levels of meteorin-like protein (Metrnl) will be measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's instructions.

Study Details

Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are chronic inflammatory diseases within the spectrum of spondyloarthritis, characterized by immune-mediated inflammation and progressive functional impairment. Meteorin-like protein (Metrnl) is a novel adipomyokine with potential immunomodulatory and anti-inflammatory properties; however, its role in spondyloarthritis remains incompletely understood. This study aims to evaluate serum Metrnl levels in patients with PsA and AS compared with healthy controls and to investigate their association with disease activity, inflammatory markers, and clinical manifestations. The findings may provide insights into the potential role of Metrnl as a biomarker of disease activity and inflammation in spondyloarthritis.

Key Dates

Start date
Jul 1, 2026
Status verified
Jun 2026
Primary completion
Jul 1, 2026
Completion
Jul 30, 2026

Study Design

Enrollment
90 participants (estimated)

Arms

  • Arm: psoriatic arthritis patients
  • Arm: Ankylosing spondylitis Patients
    AS diagnosed according to the modified New York criteria
  • Arm: control
    apparentely healthy controls

Primary Outcome Measure

• Serum IL41 differences among AS, PsA, and controls [ Time Frame: 1month ]

Central Contacts

  • Sara Farrag lecturer of rheumatology and rehabilitation, lecturer
    +01097767735
    [email protected]

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