Cannabis and Opioid Use Disorder, Study 2

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
University of Kentucky
Study ID
NCT07661446
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Cannabis Use
  • Opioid Use Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Inhaled Cannabis — DRUG
    Participants will receive inhaled cannabis and placebo
  • Intranasal Opioid — DRUG
    Participants will receive intranasal opioids and placebo

Study Details

This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks. During this time, we will examine how repeated doses of oral cannabis and acute doses of oral and inhaled cannabis 1) modify the intensity and time course of opioid withdrawal, 2) modify the effects of intranasal opioid administration and 3) impact the safety of opioid administration.

Key Dates

First listed
Jun 22, 2026
Start date
Jul 30, 2026
Status verified
Jun 2026
Primary completion
Jul 30, 2029
Completion
Jan 30, 2030

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Oral cannabis (placebo)
    Participants will receive placebo oral cannnabis
  • Experimental: Oral cannabis (active)
    Participants will receive active oral cannabis

Primary Outcome Measure

Opioid withdrawal severity [ Time Frame: This outcome will be assessed regularly from baseline through 6 hours post cannabis dose during experimental sessions. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of KentuckyLexingtonKentucky40508
Paul Nuzzo
[email protected]
859-323-0002
Shanna Babalonis, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Kentucky· Lexington, KY

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