Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
Hannah Harris
Study ID
NCT07694466
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Biomarkers
  • Cannabis Use
  • Tobacco

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Cannabis (THC) — DRUG
    Active Cannabis (THC) will be inhaled.
  • Tobacco Cigarette — DRUG
    A leading brand of tobacco cigarette (\~1.0 gram; Marlboro Gold; Phillip Morris International)

Study Details

This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.

Key Dates

First listed
Jul 10, 2026
Start date
Sep 1, 2026
Status verified
Jul 2026
Primary completion
Feb 1, 2027
Completion
Jun 1, 2027

Study Design

Enrollment
12 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Tobacco Cigarette
    Participants will inhale a leading brand of tobacco cigarette (\~1.0 gram; Marlboro Gold; Phillip Morris International).
  • Experimental: Vaporized Cannabis (THC)
    Participants will receive a non-therapeutic, active vaporized marijuana.
  • Experimental: Combustible Cannabis (THC)
    Participants will receive a non-therapeutic, active smoked marijuana.

Primary Outcome Measure

Exhaled Breath Condensate (EBC) [ Time Frame: Baseline (prior to study drug admission), approximately 25, 40,60, 90, 120 and 180 minutes after drug administration ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of KentuckyLexingtonKentucky40508-

Find similar trials in Lexington, KY

By research site
University of Kentucky· Lexington, KY

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