Low-Dose Radiotherapy for Alzheimer's Disease

Part of paid clinical trials in Winter Park, Florida.

Sponsor
Evan Thomas
Study ID
NCT07693140
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Low Dose Radiation Therapy — RADIATION
    Low dose whole brain radiotherapy delivered as an induction course of 10 fractions followed by 12 months of monthly maintenance LDRT in 10 fractions starting 2 months post-induction

Study Details

To evaluate the safety and tolerability of low-dose whole brain radiotherapy (WBRT) delivered as an induction course of 0.3 Gy × 10 fractions (3.0 Gy total) followed by 12 months of monthly maintenance LDRT (0.3 Gy × 10 fractions; 3.0 Gy total) in patients with Alzheimer's disease or dementia with inflammatory components

Key Dates

First listed
Jul 9, 2026
Start date
Jul 15, 2026
Status verified
Jul 2026
Primary completion
May 21, 2029
Completion
May 21, 2029

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment Group
    Low dose radiotherapy in 10 induction treatments followed by 10 maintenance treatments spread across each month starting at 2 month post- induction

Primary Outcome Measure

Safety, As Measured By Incidence of Grade 3 or Higher Treatment-Related Adverse Events [ Time Frame: From the first induction radiotherapy fraction through 30 days after the final monthly maintenance fraction (acute monitoring period), approximately 13 to 15 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Renaissance Institute of Precision Oncology & RadiosurgeryWinter ParkFlorida32789
Julia Pierson, BS
[email protected]
321-972-1102

Find similar trials in Winter Park, FL

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Renaissance Institute of Precision Oncology & Radiosurgery· Winter Park, FL

Related Studies