Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task

Part of paid clinical trials in Memphis, Tennessee.

Sponsor
St. Jude Children's Research Hospital
Study ID
NCT07701694
Status
Recruiting
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Conditions

  • Urea Cycle Disorder

Eligibility Criteria

Sex
ALL
Age
16 Years - 40 Years
Healthy Volunteers
Accepted

Study Details

This study is being done to understand how the brain works while people with urea cycle disorder (UCD) perform driving tasks that range from easy to difficult and to look at how that compares to traditional tests of thinking and attention.

Key Dates

First listed
Jul 14, 2026
Start date
Jul 15, 2026
Status verified
Jul 2026
Primary completion
Aug 31, 2031
Completion
Aug 31, 2032

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: UCD group
    Participants with urea cycle disorders (UCD) who meet the Eligibility Criteria and consent to participate
  • Arm: Control group
    Healthy controls who meet the Eligibility Criteria and consent to participate

Primary Outcome Measure

Changes in Oxyhemoglobin (HbO), Deoxyhemoglobin (HbR) and Total Hemoglobin (HbT) concentrations in the right and left prefrontal cortex in participants with urea cycle disorders (UCD) compared to healthy control volunteers [ Time Frame: Day 1, during driving simulator task ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
St. Jude Children's Research HospitalMemphisTennessee38105
Jean Laboe, RN
[email protected]
901-595-1693

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By research site
St. Jude Children's Research Hospital· Memphis, TN

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