Arterial Stiffness and Endothelial Function in Heart Failure

Sponsor
Coventry University
Study ID
NCT07713719
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • Study Assessment — OTHER
    * Collection of demographic details (age, sex, ethnicity, alcohol consumption, and smoking status) * Collection of previous/existing results from the participants medical records will include the following: * Medical History: Documented diagnoses, comorbidities, and history of cardiovascular conditions. * Concomitant Medications: Details of all current prescribed and over-the-counter medications relevant to their clinical care. * Physical Examination and Vital Signs: Blood pressure, pulse rate, and any other routinely recorded cardiovascular parameters available within their clinical record. All data will be collected only from information already recorded as part of routine clinical care. In addition to these, the participant will undergo the study assessments: Arterial stiffness, endothelial function, Cardiac output response to stress test and Voice recognition.

Study Details

Heart Failure (HF) is a global condition affecting at least 26 million people worldwide. Despite advances in treatment, HF patients continue to experience poor health outcomes. This study aims to improve understanding of the role of blood vessels in people with heart failure. The study will assess how arterial stiffness (how stiff blood vessels are) and endothelial function (how well the lining of blood vessels functions) change over time and respond to treatments received as part of routine clinical care. Blood vessel function and heart performance will be assessed at three time points: * At baseline (when Patients are first diagnosed with heart failure). * After completing 4 ± 2 weeks of heart-failure medicines prescribed to patients as part of their routine clinical care. * After completion of cardiac rehabilitation program as a part of their routine clinical care. All assessments are non-invasive.

Key Dates

First listed
Jul 20, 2026
Start date
Aug 31, 2026
Status verified
Jul 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Heart Failure with reserved ejection fraction
  • Arm: Heart failure with preserved ejection fraction

Primary Outcome Measure

Change in Arterial stiffness measured by Pulse wave velocity (PWV) using SphygmoCor [ Time Frame: Up to 12 week ]

Central Contacts

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