Impact of Exercise on Muscle Metabolism and Function for Persons With Parkinsons

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT07720713
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Home Exercise Program — OTHER
    All participants completed a four-week, home-based progressive strengthening program targeting GM using high-volume bodyweight exercise. Participants were instructed to perform exercises three times per week, with at least one day of rest between exercise sessions. During weeks 1 and 2, participants performed two sets of heel raises to fatigue at their prescribed level, corresponding to a subjective effort rating of 8/10. The goal was to progress toward completing 20 repetitions per set. Exercise loading was individualized based on baseline performance and adjusted throughout the intervention according to each participant's demonstrated strength progression.

Study Details

This investigation assesses the impact of a strengthening program on muscle metabolism in the gastrocnemius muscle (GM) and is an essential step in the establishment of future clinical intervention for the GM in people with Parkinson's disease (with healthy peers as the control group). The participants will be provided with a progressive GM strengthening program while monitoring muscle metabolism and functional changes before and after intervention.

Key Dates

First listed
Jul 22, 2026
Start date
Apr 27, 2022
Status verified
Jul 2026
Primary completion
Jun 30, 2023
Completion
Jun 30, 2023

Study Design

Enrollment
19 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Home exercise program
    Home exercise program for gastrocnemius strengthening

Primary Outcome Measure

Muscle metabolic properties (P-31 MRS) [ Time Frame: Day 1 (baseline) and 4 weeks (post exercise program) ]

Locations (1)

FacilityCityStateZIPSite coordinators
UT Southwestern Medical CenterDallasTexas75235-

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By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
UT Southwestern Medical Center· Dallas, TX

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