Screen2Prevent (S2P)

Conditions

• HIV Infections

Eligibility Criteria

Sex

ALL

Age

14 Years - 24 Years

Healthy Volunteers

Accepted

Interventions

• HIV screening strategies — OTHER
  The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months. A targeted screening approach is defined as screening those who are at increased likelihood for acquiring HIV. Alternatively, a universally offered screening approach is defined as screening all, regardless of behavior informing risk. There are two types of universally offered screening, opt-in and opt-out. With opt-in screening, all patients are offered screening, which they may then agree to undergo. Opt-out screening consists of notifying patients that the test will be conducted unless they explicitly decline. Each screening strategy implements the cSHS, a text messaging platform, and Clinical Decision Support for identification of youth needing HIV treatment/prevention and linkage to services.

Study Details

Screen2Prevent is a study intended to improve HIV prevention and detection through implementation and evaluation of three different broad-scale HIV screening approaches a) targeted, b) universally offered opt-in, and c) universally offered opt-out in Emergency Departments (EDs) by leveraging digital health to identify and link adolescents seeking care in the ED to HIV Pre-Exposure Prophylaxis (PrEP)/Antiretroviral treatment (ART).

Key Dates

First listed

Jul 27, 2026

Start date

Jun 16, 2026

Status verified

Jul 2026

Primary completion

Oct 31, 2028

Completion

Oct 31, 2028

Study Design

Enrollment

84,000 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Arms

• Other: 1. Universally offered opt-in > Universally offered opt-out > Targeted
  The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.
• Other: 2. Universally offered opt-out > Universally offered opt-in > Targeted
  The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.
• Other: 3. Universally offered opt-in > Targeted > Universally offered opt-out
  The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.
• Other: 4. Universally offered opt-out > Targeted > Universally offered opt-in
  The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.
• Other: 5. Targeted > Universally offered opt-out > Universally offered opt-in
  The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.
• Other: 6. Targeted > Universally offered opt-in > Universally offered opt-out
  The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.

Primary Outcome Measure

Monthly HIV detection rates per 1,000 eligible patients [ Time Frame: 36 months ]

Central Contacts

• Erin Ricketts
  240-453-2786
  [email protected]
• Nancy Liu
  718-980-3937
  [email protected]

Locations (5)

Find similar trials in Tampa, FL

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