RISE: Reducing Cancer and HIV Stigma Through Empowerment

Part of paid clinical trials in Houston, Texas.

Sponsor: M.D. Anderson Cancer Center
Study ID: NCT07728370
Status: Not Yet Recruiting

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Conditions

Cervical Cancer Stigma
HIV

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Neutral Video — BEHAVIORAL
Participants in the control group will watch neutral videos and describe objective, non-emotional objects/events
Storytelling — BEHAVIORAL
The storytelling intervention group will watch the storytelling videos and then describe objective, non-emotional objects/events.
Self disclosure — BEHAVIORAL
Participants will watch neutral videos and then talk/write about their cancer/HIV-related experiences to themselves.
Combination — BEHAVIORAL
The combination group will watch the storytelling videos and then talk/write about their cancer/HIV-related experiences to themselves.
Video — BEHAVIORAL
Participants (healthcare workers) will watch storytelling videos in a group setting, followed by a facilitated discussion and role-playing to enhance empathy and understanding.
Waitlist — BEHAVIORAL
Participants will watch unrelated presentations in a group setting while on a waitlist. They will receive the intervention after completing the post-test.

Study Details

This multilevel randomized behavioral study evaluates participant- and provider-level stigma-reduction interventions in Zambia. Participant-level intervention: Women living with cervical cancer and HIV (WLC+H ) are randomized in a 2×2 factorial design of storytelling versus neutral videos and storytelling versus neutral disclosure interventions to assess effects on quality of life, anxiety, and depressive symptoms. Provider-level intervention: Healthcare workers are randomized to storytelling or neutral videos to assess changes in stigma and compassion. The study also evaluates participant -reported stigma and satisfaction with care before and after implementation of the provider intervention.

Key Dates

First listed: Jul 27, 2026
Start date: Sep 1, 2026
Status verified: Jun 2026
Primary completion: May 31, 2030
Completion: Aug 31, 2030

Study Design

Enrollment: 440 participants (estimated)
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: SUPPORTIVE_CARE

Arms

Experimental: Patient control group - neutral videos
Experimental: Patient storytelling group
Experimental: Patient self-disclosure group
Experimental: Patient combination group - storytelling video and storytelling disclosure
Experimental: Provider Storytelling group
Experimental: Provider waitlist control group