Effects of IMT on Cardiopulmonary Endurance and Functional Mobility in KOA

Sponsor
Riphah International University
Study ID
NCT07738627
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
40 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • POWERBREATH — DEVICE
    The POWERBREATH devices utilize calibrated resistance valves to force your breathing muscles to work harder, which naturally builds their power, stamina, and efficiency. IMT through POWERbreathe * 30 quick breaths two times a day at an adjustable resistance (equivalent to∼50% of (baseline) MIP). * Increased up to 35 breaths as per patient's tolerance.
  • SHAM IMT — DEVICE
    * 60 slow breaths once daily at a load setting of 0 (corresponding to∼15% (baseline) MIP). * Training load adjustment was prevented using sticky tape applied to the device's load adjuster.

Study Details

The purpose of the study is to investigate whether adding Inspiratory Muscle Training (IMT) to the usual treatment of patients with knee osteoarthritis improves their cardiopulmonary endurance and functional mobility more than standard care alone.

Key Dates

First listed
Jul 31, 2026
Start date
Aug 31, 2026
Status verified
Aug 2026
Primary completion
Jan 5, 2027
Completion
Dec 11, 2027

Study Design

Enrollment
65 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Inspiratory Muscle Training (IMT) + Conventional Knee OA Physiotherapy
    Participants will receive conventional knee osteoarthritis physiotherapy twice weekly for 6 weeks along with Inspiratory Muscle Training (IMT) using a POWERbreathe device. IMT will consist of 30 quick breaths twice daily at approximately 50% of baseline maximal inspiratory pressure (MIP), progressively increased up to 35 breaths according to patient tolerance. Conventional treatment includes knee isometric exercises, open-chain strengthening exercises, static stretching, and Maitland Grade I-II anterior-posterior mobilizations.
  • Sham Comparator: Sham IMT + Conventional Knee OA Physiotherapy
    Participants will receive conventional knee osteoarthritis physiotherapy twice weekly for 6 weeks along with sham inspiratory muscle training using a POWERbreathe device. Sham training will consist of 60 slow breaths once daily at load setting zero (approximately 15% of baseline MIP). The load adjuster will be fixed with adhesive tape to prevent resistance progression. Conventional treatment will be identical to the experimental group

Primary Outcome Measure

Six-Minute Walk Test Assessment of cardiopulmonary endurance and aerobic capacity. Time Frame: Baseline, Week 3, Week 6 Six-Minute Walk Test (6MWT) Assessment of cardiopulmonary endurance and aerobic capacity. Time Frame: Baseline, Week 3, Wee [ Time Frame: Baseline, Week 3, Week 6 ]

Central Contacts

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