15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis

Sponsor
Assiut University
Study ID
NCT07751263
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

To evaluate serum and synovial fluid 15-PGDH levels in patients with osteoarthritis and ankylosing spondylitis and determine their associations with clinical and musculoskeletal ultrasound features. To compare 15-PGDH concentrations among patients with knee osteoarthritis, and ankylosing spondylitis with knee effusion To evaluate whether serum 15-PGDH reflects intra-articular 15-PGDH concentrations. Analysis the level of 15-PGDH in relation to disease activity and severity of both diseases.

Key Dates

First listed
Aug 7, 2026
Start date
Aug 2, 2026
Status verified
Aug 2026
Primary completion
Aug 2, 2027
Completion
Aug 2, 2028

Study Design

Enrollment
51 participants (estimated)

Arms

  • Arm: • Arm 1: Osteoarthritis • Arm 2: Ankylosing spondylitis • Arm 3: Healthy controls
    Three analytical study arms: OA, AS, and control groups.

Primary Outcome Measure

Serum 15-hydroxyprostaglandin dehydrogenase (15-PGDH) levelr [ Time Frame: 2 years ]

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