Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms

Part of paid clinical trials in New York, New York.

Sponsor: NYU Langone Health
Study ID: NCT07752355
Status: Recruiting

Conditions

Parkinson Disease
Young Onset Parkinson Disease

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Accepted

Study Details

Young Onset Parkinson's disease (YOPD) refers to a group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient's life. Current knowledge regarding the mechanisms leading to development of Parkinson's disease in younger individuals is lacking, but their understanding is crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. With this research the investigators aim to clarify the contribution of relevant biological processes in patients with Young onset Parkinson's disease to help understanding disease mechanisms and biomarkers.

Key Dates

First listed: Aug 7, 2026
Start date: Feb 28, 2024
Status verified: Aug 2026
Primary completion: Oct 31, 2028
Completion: Oct 31, 2028

Study Design

Enrollment: 250 participants (estimated)

Arms

Arm: Young-Onset Parkinson's Disease (YOPD) Patients
Clinical assessment: * History of PD * Medical history * Assessment of motor and non-motor symptoms of PD through standard rating scales Biological samples: * Peripheral blood sample for the study of genetic and multi-omics data * Skin punch biopsy (3mm) for the assessment of the Alpha-Synuclein seeding amplification (SAA) Assay For a sub-cohort of subjects: \- Lumbar puncture for the collection of spinal fluid for the study of biological profiles
Arm: Late-Onset Parkinson's Disease (LOPD) Patients
Clinical assessment: * History of PD * Medical history * Assessment of motor and non-motor symptoms of PD through standard rating scales Biological samples: * Peripheral blood sample for the study of genetic and multi-omics data * Skin punch biopsy (3mm) for the assessment of the Alpha-Synuclein seeding amplification (SAA) Assay For a sub-cohort of subjects: Lumbar puncture for the collection of spinal fluid for the study of biological profiles
Arm: Healthy Controls
Clinical assessment: * Medical history * Assessment of motor and non-motor symptoms of PD through standard rating scales Biological samples: * Peripheral blood sample for the study of genetic and multi-omics data * Skin punch biopsy (3mm) for the assessment of the Alpha-Synuclein seeding amplification (SAA) Assay For a sub-cohort of subjects: Lumbar puncture for the collection of spinal fluid for the study of biological profiles