Alzheimer's Disease Research Center (ADRC) PET Component Study

Part of paid clinical trials in New York, New York.

Sponsor
Patrick Lao
Study ID
NCT07758660
Phase
PHASE2
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • 18F-MK6240 — DRUG
    MK-6240 is experimental but has been used in several human studies before and has been proven to accurately measure tau in the brain.
  • 18F-Florbetaben (FBB) — DRUG
    Florbetaben has been approved by the FDA to help diagnose Alzheimer's disease. Florbetaben measures amyloid in the brain.

Study Details

The purpose of this study is to further engage and characterize Alzheimer's Disease Research Center (ADRC) participants through additional research opportunities, particularly PET imaging. Amyloid and Tau PET imaging will be collected in 24 participants per year, for a total of 120 participants over five years. All participants will be followed longitudinally, including through potential transitions from normal aging to mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD).

Key Dates

First listed
Aug 11, 2026
Start date
Aug 6, 2026
Status verified
Aug 2026
Primary completion
May 31, 2031
Completion
May 31, 2033

Study Design

Enrollment
120 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Cognitive impairment
    Participants with Alzheimer's disease and related disorders, including but not limited to: Frontotemporal dementia, Lewy Body dementia, Creutzfeldt-Jakob disease, other dementias, and subjective or objective features of mild cognitive change.
  • Active Comparator: No cognitive impairment
    Healthy elderly controls and nonpatient volunteers with subjective or objective features of normal aging.

Primary Outcome Measure

18F-FBB Standardized Uptake Value Ratio [ Time Frame: Up to 12 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032-

Find similar trials in New York, NY

Nationwide
Alzheimer's disease trialsNeurology trialsDementia care trialsBrain disorders trialsGeriatrics trials
By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Columbia University Irving Medical Center· New York, NY

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