Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

Conditions

• Surgery, Upper Extremity

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Toradol — DRUG
  Regional Nerve Block + Toradol + Acetaminophen
• Oxycodone — DRUG
  Regional Nerve Block + Oxycodone + Acetaminophen

Study Details

The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block. Ketorolac (Toradol) is a nonsteroidal anti-inflammatory drug (NSAID) that is similar to ibuprofen (Motrin or Advil). Tylenol (acetaminophen) is a commonly used over the counter drug. A nerve block is pain medication that is applied directly to the nerves around the surgical site before the surgery and keeps working to reduce pain in the area for several hours after the surgery. All of these medicines and procedures are approved by the Food and Drug Administration (FDA) for patient care. This study aims to understand if using these medicines in combination helps patients having hand and wrist surgery avoid the need for opioid pain medications.

Key Dates

First listed

Aug 19, 2026

Start date

Mar 17, 2025

Status verified

Aug 2026

Primary completion

Feb 28, 2027

Completion

Feb 28, 2027

Study Design

Enrollment

120 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

TREATMENT

Arms

• Experimental: Non-Opioid
  Regional Nerve Block + Ketorolac (Toradol) + Tylenol (acetaminophen)
• Active Comparator: Opioid
  Regional Nerve Block + Oxycodone (5mg, 10 tablets) + Tylenol (acetaminophen)

Primary Outcome Measure

Postoperative Pain, as measured by the Numeric Pain Scale [ Time Frame: 2 days, 1 week and 2 weeks post op ]

Central Contacts

• Jennifer Wolf, MD
  773-795-3583
  [email protected]

Locations (1)

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