Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma Patients

Part of paid clinical trials in Duarte, California.

Sponsor
City of Hope Medical Center
Study ID
NCT07775534
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Biospecimen Collection — PROCEDURE
    Undergo collection of tears
  • Biospecimen Collection — PROCEDURE
    Undergo collection of blood and standard of care CSF samples
  • Electronic Health Record Review — OTHER
    Ancillary studies
  • Questionnaire Administration — OTHER
    Ancillary studies

Study Details

This clinical trial tests the impact of tear fluid in detecting tumor-associated extracellular vesicles (TEVs) in patients with glioblastoma. Brain tumors release small particles, called TEVs, that may provide information about the tumor, including how it responds to treatment. These particles can be found in cerebrospinal fluid (CSF), which is the fluid that surrounds the brain and spinal cord. Collecting CSF can be difficult and expensive, especially if samples are needed frequently to track these particles over time. Tear fluid is easier to collect than spinal fluid. If tears are found to contain similar tumor-related particles, changes in the tumor may be tracked by studying the particles found in tear fluid.

Key Dates

First listed
Aug 20, 2026
Start date
Dec 9, 2026
Status verified
Aug 2026
Primary completion
Sep 19, 2027
Completion
Sep 19, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Phase 1 (collection of tears)
    Patients and healthy controls undergo collection of tears on study.
  • Experimental: Phase 2 (collection of tears, blood, CSF)
    Patients and healthy controls undergo collection of tears and blood samples and patients undergo collection of standard of care CSF samples throughout the study.

Primary Outcome Measure

Proportion of samples containing at least 2 uL of tear (feasibility) [ Time Frame: Up to 2 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
City of Hope Medical CenterDuarteCalifornia91010
Lisa A. Feldman
[email protected]
626-218-8680
Lisa A. Feldman (PRINCIPAL_INVESTIGATOR)

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City of Hope Medical Center· Duarte, CA

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