Effects of Kefir on Celiac Disease

Sponsor
University Maribor
Study ID
NCT07777666
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • kefir — DIETARY_SUPPLEMENT
    Participants will consume 200 mL kefir prepared from starter cultures daily for 4 weeks. The kefir will be provided for the intervention period.

Study Details

This study will investigate whether regular consumption of kefir can reduce gastrointestinal symptoms and improve quality of life in adults with celiac disease who follow a strict gluten-free diet. The study will use a randomized cross-over design in which participants will consume kefir during one study period and continue their usual diet without kefir during another period.

Key Dates

First listed
Aug 20, 2026
Start date
Sep 30, 2026
Status verified
Aug 2026
Primary completion
May 31, 2027
Completion
Nov 29, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Kefir first
    Participants randomized to this sequence will consume kefir daily for 4 weeks, followed by a 4-week washout period and then 4 weeks of their usual gluten-free diet without kefir.
  • Experimental: No Kefir First
    Participants randomized to this sequence will follow their usual gluten-free diet without kefir for 4 weeks, followed by a 4-week washout period and then 4 weeks of daily kefir consumption.

Primary Outcome Measure

Change in gastrointestinal symptoms assessed by the Gastrointestinal Symptom Rating Scale (GSRS) [ Time Frame: Baseline, after each 4-week intervention period, and after the 4-week washout period ]

Central Contacts

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