tACS and Upper Limb Rehabilitation in Chronic Stroke

Sponsor
National University Hospital, Singapore
Study ID
NCT07778342
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • tACS — DEVICE
    . tACS will be delivered at a maximum intensity of 1 mA (peak-to-peak) at a frequency corresponding to the individual peak motor imagery (MI) performance frequency. 12 sessions of tACS will be conducted 3 times a week within 4-6 weeks.
  • Sham — DEVICE
    Sham mode of the tACS stimulator will be turned on for sham stimulation.

Study Details

This study tests whether a brain stimulation technique called tACS can help stroke patients recover movement in their affected arm. Patients receive either real or fake brain stimulation three times a week for about a month (12 sessions total). During each session, they wear a cap with electrodes that deliver mild electrical currents tailored to their individual brain patterns, while researchers monitor their brain activity. The study measures progress at three time points: before treatment, right after treatment, and one month later. Researchers use brain stimulation tests to check how well the brain controls muscles, and conduct physical tests to measure arm movement, muscle stiffness, and grip strength.

Key Dates

First listed
Aug 21, 2026
Start date
Dec 1, 2026
Status verified
Aug 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
34 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: real tACS
    tACS will be delivered at a maximum intensity of 1 mA (peak-to-peak) at a frequency corresponding to the individual peak motor imagery (MI) performance frequency.
  • Sham Comparator: sham tACS
    sham tACS mimics active stimulation by delivering short periods of current matching the active protocol) with brief ramp-up and ramp-down periods at the very beginning and end of the session to replicate initial skin tingling sensations.

Primary Outcome Measure

Upper Extremities Fugl-Meyer Assessment (UE-FMA) [ Time Frame: Week 0 ]

Central Contacts

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