Alcohol, Breast Cancer, and Metabolism

Part of paid clinical trials in Urbana, Illinois.

Sponsor
University of Illinois at Urbana-Champaign
Study ID
NCT07779967
Status
Recruiting
Apply to this trial

Conditions

  • Alcohol Drinking
  • Breastfeeding
  • Ethanol Intoxication

Eligibility Criteria

Sex
FEMALE
Age
21 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Low-alcohol level exposure — OTHER
    Participants will consume a protocol-specified low-level alcohol exposure under study conditions. The assigned dose and biospecimen collection procedures will vary by study group.
  • Breast-pumping time — OTHER
    Breast pumping before or after drinking \~ 1 standard drink or placebo drink

Study Details

Alcohol consumption, even at low levels, has been associated with increased breast cancer risk, but the biological mechanisms underlying this relationship remain unclear. This study will examine whether breast tissue may locally metabolize alcohol by measuring alcohol-related compounds in paired blood and breast milk samples from lactating women. The findings may help clarify alcohol-related biological pathways relevant to breast cancer risk and improve risk communication.

Key Dates

First listed
Aug 21, 2026
Start date
Sep 3, 2026
Status verified
Sep 2026
Primary completion
Jul 13, 2031
Completion
Mar 1, 2032

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Arm 1: lactating women dose response
    Lactating women who will drink \~0, 1 or 2 standard drinks of alcohol
  • Experimental: Arm 2: timing of pumping
    Lactating women will pump at two different times from alcohol drinking and at one of these times after placebo drinking
  • Other: Aim 3: non-lactating control women
    Non-lactating women of similar age, BMI, and alcohol consumption characteristics will drink a similar dose of alcohol as lactating women for the assessment of systemic alcohol-related measurements. This group will serve as a comparison group for interpreting alcohol-related measurements in lactating participants.

Primary Outcome Measure

Blood alcohol concentrations [ Time Frame: 2- 3 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Bevier Hall; University of Illinois at Urbana ChampaignUrbanaIllinois61801
Marta
[email protected]
217-300-2374
Eva Hu, BS
[email protected]
217-300-4709

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By research site
Bevier Hall; University of Illinois at Urbana Champaign· Urbana, IL

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