A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early Alzheimer's Disease After Multiple Dose Administration

Part of paid clinical trials in Anaheim, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT07780383
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • BMS-986446 — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the drug levels, absolute bioavailability, safety, tolerability, and immunogenicity of single-Dose of BMS-986446 in healthy adults after single-dose administration, and participants with early Alzheimer's Disease after multiple dose administration

Key Dates

First listed
Aug 21, 2026
Start date
Aug 21, 2026
Status verified
Aug 2026
Primary completion
Jun 17, 2027
Completion
Jun 17, 2027

Study Design

Enrollment
84 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Panel A1: BMS986446
  • Experimental: Panel A2: BMS986446
  • Experimental: Panel A3: BMS986446
  • Experimental: Panel B1: BMS986446
  • Experimental: Panel B2: BMS986446
  • Experimental: Panel C1: BMS986446

Primary Outcome Measure

Absolute bioavailability estimated from geometric mean ratio (GMR) of area under the concentration-time curve from time zero extrapolated to infinite time (AUC(INF)) of BMS-986446 after subcutaneous (SC) infusion [ Time Frame: Up to approximately 5 months ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (1)

FacilityCityStateZIPSite coordinators
Local Institution - 0001AnaheimCalifornia92801
Site 0001

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By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Local Institution - 0001· Anaheim, CA

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