Long-Term Study of COVID-19 Infection and Long COVID

Conditions

• SARS CoV-2 Post-Acute Sequelae

Eligibility Criteria

Sex

ALL

Age

18 Years - 75 Years

Healthy Volunteers

Not accepted

Interventions

• This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms. — OTHER
  Other:

Study Details

This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19. Researchers will collect information about participants' health and symptoms through questionnaires and may collect saliva and other non-invasive oral samples. The study will also examine biological factors in these samples that may be associated with persistent symptoms. The goal is to better understand why some people develop Long COVID and identify factors that may help predict who is more likely to experience persistent symptoms.

Key Dates

First listed

Aug 24, 2026

Start date

Sep 4, 2024

Status verified

Aug 2026

Primary completion

Dec 31, 2028

Completion

Dec 31, 2029

Study Design

Enrollment

500 participants (estimated)

Arms

• Arm: COVID-19+
  Adults who have previously had COVID-19 and may be experiencing ongoing symptoms or changes in their health following infection.

Primary Outcome Measure

Salivary Proteomic Profile [ Time Frame: During active infection through three months post infection ]

Central Contacts

• Laura A Jacox, PhD, DMD, MS
  +1 847-702-0988
  [email protected]
• Jeannene L Matthews, MA, M.Ed., CCC-SLP
  +1 919-357-5999
  [email protected]

Locations (1)

Find similar trials in Chapel Hill, NC

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• Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection
  EARLY_PHASE1 · Recruiting · University of Alabama at Birmingham · Birmingham, Alabama