Reducing Cardiovascular Risks: The Role of Alcohol Use

Part of paid clinical trials in Arlington, Texas.

Sponsor: The University of Texas at Arlington
Study ID: NCT07783061
Status: Not Yet Recruiting

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Conditions

Alcohol Drinking
At-risk Drinking
Cardiovascular Risk Factor
Drinking Behavior
High Blood Pressure

Eligibility Criteria

Sex: ALL
Age: 26 Years - 49 Years
Healthy Volunteers: Not accepted

Interventions

Alcohol Abstinence — BEHAVIORAL
Participants will be instructed to abstain from alcohol for 8 weeks and maintain their usual lifestyle, including diet and physical activity. One week before the intervention, participants will be provided with an Oura Ring and instructed to wear it throughout the study. Every two weeks, participants will meet virtually with the research team (approximately 45 minutes) to receive educational materials and personalized feedback based on phosphatidylethanol (PEth), sleep, and heart rate variability data to support alcohol abstinence. During these meetings, participants will also complete assessments of alcohol use, physical activity, and dietary intake. At week 4, participants will complete a dried blood spot PEth test. Participants will also receive weekly reminders by text message or email to ensure Oura Ring data are uploaded successfully.
Control arm — OTHER
Participants will be asked to maintain their usual lifestyle, including alcohol consumption, diet, and physical activity, and will not have access to their study data during the intervention. One week before the intervention, participants will be provided with an Oura Ring and instructed to wear it throughout the study. Every two weeks, participants will meet virtually with the research team (approximately 45 minutes) to complete questionnaires on alcohol use, physical activity, and diet. At week 4, participants will complete a dried blood spot phosphatidylethanol (PEth) test. Participants will also receive weekly reminders by text message or email to ensure Oura Ring data are uploaded successfully.

Study Details

The purpose of this study is to learn whether avoiding alcohol can improve heart and blood vessel health in adults who regularly drink alcohol and have high blood pressure. High blood pressure is a major risk factor for cardiovascular disease (CVD), including heart attack and stroke. In this randomized, controlled trial, men and women aged 26 to 49 years who regularly consume alcohol and have high blood pressure will be assigned by chance to either stop drinking alcohol or continue their usual drinking habits for 8 weeks. Researchers will compare changes in blood pressure and other cardiovascular disease risk factors between the two groups. The information gained from this study may help researchers and health care providers better understand the effects of alcohol consumption on cardiovascular health and whether alcohol abstinence can reduce heart disease risk, especially in adults with high blood pressure.

Key Dates

First listed: Aug 24, 2026
Start date: Oct 31, 2026
Status verified: Aug 2026
Primary completion: Aug 31, 2031
Completion: Sep 30, 2031

Study Design

Enrollment: 148 participants (estimated)
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Arms

Other: Usual Drinking Habits (Control)
Participants will continue their usual alcohol consumption patterns during the study period and will be instructed not to change their lifestyle including alcohol use, diet, and habitual physical activity.
Experimental: Alcohol Abstinence Intervention
Participants will be instructed to abstain from alcohol for 8 weeks. Throughout the study period, participants will be asked to maintain their usual diet and level of physical activity and avoid making other lifestyle changes, except for abstaining from alcohol.