A Study of Armored CAR T Cells in People With Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07783477
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • DLL3-SAVVYZ-IL18 CAR T cell — DRUG
    DLL3-SAVVYZ-IL18 CAR T cell

Study Details

The purpose of this study is to test the safety of DLL3-SAVVYZ-IL18 in people with DLL3+ cancer.

Key Dates

First listed
Aug 24, 2026
Start date
Sep 30, 2026
Status verified
Aug 2026
Primary completion
Sep 30, 2029
Completion
Sep 30, 2029

Study Design

Enrollment
16 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Dose Level 1
    This is the starting dose of DLL3-SAVVYZ-IL18 CAR T cell Dose
  • Experimental: Dose Level 2
    Eligible participants will receive DLL3-SAVVYZ-IL18 CAR T cell Dose at this Dose Level if no Dose Limiting Toxicities are experienced at Dose Level 1
  • Experimental: Dose Level -1
    Eligible participants will receive DLL3-SAVVYZ-IL18 CAR T cell Dose at this Dose Level if Dose Limiting Toxicities are experienced at Dose Level 1

Primary Outcome Measure

Maximum Tolerated Dose/MTD of DLL3-SAVVYZ-IL18 CAR T cell [ Time Frame: up to 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Adam Schoenfeld, MD
[email protected]
646-608-4042
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Adam Schoenfeld, MD
[email protected]
646-608-4042
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Adam Schoenfeld, MD
[email protected]
646-608-4042
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited Protocol Activities)CommackNew York11725
Adam Schoenfeld, MD
[email protected]
646-608-4042
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Adam Schoenfeld, MD
[email protected]
646-608-4042
Memorial Sloan Kettering Cancer Center (All protocol activities)New YorkNew York10065
Adam Schoenfeld, MD
[email protected]
646-608-4042
Memorial Sloan Kettering Cancer Center @ Nassau (Limited Protocol Activities)UniondaleNew York11553
Adam Schoenfeld, MD
[email protected]
646-608-4042

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