Endovascular Treatment for Acute Large Vessel Occlusion With Ultra-Large Ischemic Core

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Patients assigned to the EVT group should undergo EVT as soon as possible, followed by BMM according to the current EVT guidelines. — PROCEDURE
EVT should be performed as soon as possible in patients randomized to the EVT group. Investigators and clinicians should make every effort to minimize delays related to pre-procedural preparation, with a target interval of no more than 60 minutes from randomization to arterial puncture. EVT in the EVT group can be performed with any thrombectomy device (NMPA approved) usually used at study site.
The medical group receives BMM alone. EVT is not performed in the medical group. — DRUG
The administration of medications is at the treating physician's discretion (for example intravenous fibrinolysis, anticoagulants or antiplatelet) according to current AIS management guidelines but may NOT include any intra-arterial therapies.

an investigator initiated, prospective, multicenter, randomized, open-label, blinded endpoint trial (PROBE)

The primary efficacy endpoint is the mRS score at 90 days after randomization. [ Time Frame: at 90 days after randomization. ]

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