High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease

Sponsor
Zhejiang University
Study ID
NCT07791979
Status
Not Yet Recruiting

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Conditions

  • Chronic Obstructive Pulmonary Disease (COPD)
  • Esophageal Cancer
  • Gastric Cancer (Diagnosis)
  • Hypoxemia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • High-flow nasal cannula — DEVICE
    Using high-flow nasal cannula oxygenation

Study Details

Hypoxemia is the most common adverse event during propofol sedation for gastrointestinal endoscopy in patients with chronic obstructive pulmonary disease (COPD) due to diminished pulmonary reserve. Although high-flow nasal cannula (HFNC) oxygenation has been shown to effectively reduce hypoxemia during sedated endoscopy in obese patients, its application in COPD patients remains an evidence gap, largely owing to the traditional concern that high-concentration oxygen may suppress respiratory drive and exacerbate CO₂ retention. This study aims to investigate whether HFNC can reduce the incidence of hypoxemia during sedated gastrointestinal endoscopy in patients with COPD.

Key Dates

First listed
Aug 28, 2026
Start date
Aug 29, 2026
Status verified
Aug 2026
Primary completion
Feb 23, 2027
Completion
Feb 23, 2027

Study Design

Enrollment
90 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: High-flow nasal cannula
    Using high-flow nasal cannula oxygenation

Primary Outcome Measure

The incidence of hypoxemia [ Time Frame: Patients will be followed for the duration of hospital stay, an expected average about 2 hours ]

Central Contacts

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