Daily Upgrade Trial

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT07792603
Status
Recruiting
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Conditions

  • Healthy Women

Eligibility Criteria

Sex
FEMALE
Age
25 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Essential Amino Acid+ — DIETARY_SUPPLEMENT
    Daily supplementation of essential amino acids
  • Non-Calorie Placebo — DIETARY_SUPPLEMENT
    Daily supplementation with non-caloric placebo
  • High intensity Interval Training — BEHAVIORAL
    Twice weekly high intensity interval training for 3 weeks
  • No Exercise — OTHER
    No exercise

Study Details

This study evaluates the acute and chronic effects of an essential amino acid supplement (Daily Upgrade EAA+) on metabolomics, amino acid kinetics, metabolic rate, body composition in active adult women. The study consists of an acute randomized double-blind crossover phase comparing EAA+, whey protein isolate, and placebo before high-intensity interval training (HIIT), and a chronic randomized double-blind parallel-arm phase evaluating 3 weeks of EAA+ or placebo supplementation combined with twice-weekly HIIT.

Key Dates

First listed
Aug 28, 2026
Start date
Aug 31, 2026
Status verified
Aug 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
44 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Essential Amino Acids+
    Essential amino acids, creatine, magnesium, electrolytes consumed once (daily) with 8-12 oz of water.
  • Placebo Comparator: Placebo Comparator
    Non-caloric placebo consumed once (daily) with 8-12 oz of water
  • Active Comparator: Whey Protein Isolate
    1 serving whey protein isolate mixed with 8-12 oz of water

Primary Outcome Measure

Essential Amino Acid Kinetics [ Time Frame: Baseline, 30, 60, and 90 minutes following supplementation during acute visits. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Applied Physiology LaboratoryChapel HillNorth Carolina27599
Research Coordinator
[email protected]
919-962-1663
Abbie Smith-Ryan, PhD (PRINCIPAL_INVESTIGATOR)

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Applied Physiology Laboratory· Chapel Hill, NC

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