Effects of Risk Presentation Format and Frequently Asked Questions on Breast Cancer Risk Skepticism

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT07793721
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
FEMALE
Age
39 Years - 74 Years
Healthy Volunteers
Accepted

Interventions

  • Risk Presentation Format — BEHAVIORAL
    Participants receive a personalized breast cancer risk estimate generated by the Gail Model. The format of the estimate varies by random assignment across two dimensions: temporal framing (5-year, 10-year, or lifetime risk) and denominator (risk expressed out of 100 women or out of 1,000 women). All other elements of the risk presentation are held constant across conditions.
  • Frequently Asked Questions Exposure — BEHAVIORAL
    Participants receive a personalized breast cancer risk estimate generated by the Gail Model and then view an interactive FAQ document. The FAQ document was developed from qualitative interviews with women who had previously rejected their risk estimates and addresses common questions about how breast cancer risk is calculated, what factors the model does and does not include, what different risk levels mean, and how to discuss results with a physician. FAQ items are displayed as expandable questions; participants click to reveal answers. All participants receive the same FAQ document.

Study Details

The purpose of this study is to find out whether the way a breast cancer risk estimate is presented affects how women feel about their risk and whether they believe the estimate is accurate for them. Women aged 39-74 will complete an online survey in which they receive a personalized breast cancer risk estimate using the Breast Cancer Risk Assessment Tool (BCRAT). The study includes two experiments. In the first experiment, women are randomly assigned to receive their estimate in different formats: some will see their risk over 5 years, 10 years, or a lifetime, and some will see their risk expressed out of 100 women or out of 1,000 women. In the second experiment, women receive their estimate and then have the opportunity to read answers to frequently asked questions about how breast cancer risk is calculated and what the estimate means. In both experiments, women are asked whether they believe the estimate reflects their true risk. Both experiments are conducted online through a national survey panel.

Key Dates

First listed
Aug 28, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Feb 1, 2027
Completion
Apr 1, 2027

Study Design

Enrollment
3,000 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Experimental: 5 Year Risk AND N-in-100 Presentation
  • Experimental: 10 Year Risk AND N-in-100 Presentation
  • Experimental: Lifetime Risk AND N-in-100 Presentation
  • Experimental: 5 Year Risk AND N-in-1000 Presentation
  • Experimental: 10 Year Risk AND N-in-1000 Presentation
  • Experimental: Lifetime Risk AND N-in-1000 Presentation

Primary Outcome Measure

Risk Skepticism [ Time Frame: Day 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado Anschutz Medical CampusAuroraColorado80045
Laura D Scherer, PhD
[email protected]
303-724-3278
Kate Noonan, MSW
[email protected]
303-618-2181
Laura D Scherer, PhD (PRINCIPAL_INVESTIGATOR)

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By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
University of Colorado Anschutz Medical Campus· Aurora, CO

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