Study of the Intracerebral Electrophysiological Signature in the Epileptic Patient

Sponsor
University Hospital, Toulouse
Study ID
NCT07796984
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Cognitive tasks in the form of questionnaires — OTHER
    During their hospitalization for SEEG, patients will perform cognitive tasks to assess memory, vision, attention, language, and decision-making.

Study Details

As part of the clinical management of certain severe, drug-resistant forms of epilepsy, it is necessary to implant electrodes in the brain to identify the epileptic network prior to potential neurosurgical resection of the source zones. This standardized procedure, known as Stereo-Electroencephalography (SEEG), was developed in France in the 1960s. The electrodes remain implanted for several days-typically two weeks-while awaiting spontaneous epileptic seizures. During this period, the patient remains hospitalized, and their electroencephalographic activity is recorded around the clock. Patients can be asked to perform cognitive tasks (such as tasks involving memory, attention, vision, language, and decision-making) while awake or asleep; the results can then be correlated with the intracerebral electroencephalographic activity recorded simultaneously as part of their clinical care. This approach makes it possible to capture the electrophysiological signatures of specific cognitive processes, thereby enabling researchers to: 1) create a brain map of electrophysiological signatures, 2) improve standard models of cognitive function, and 3) study the dysfunction of these processes in epilepsy.

Key Dates

First listed
Sep 1, 2026
Start date
Oct 1, 2026
Status verified
Aug 2026
Primary completion
Oct 1, 2031
Completion
Oct 31, 2031

Study Design

Enrollment
75 participants (estimated)

Arms

  • Arm: Patients hospitalized for SEEG with cognitive tasks

Primary Outcome Measure

Construction of a database of electrophysiological signatures of various cognitive functions [ Time Frame: 3 weeks after the inclusion ]

Central Contacts

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