Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma

Sponsor
University Hospital, Bordeaux
Study ID
NCT07802769
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • MRI — DEVICE
    MRI

Study Details

The EVOLUTION is a 10-year extension of the ENVOL study. It seeks to compare the evolution of structural and functional connectivity (Hub Disruption Index) and cerebral volume on 3T MRI of the brain in glaucoma patients and matched controls. The study aims to examine the hypothesis that glaucomatous optic neuropathy is not limited solely to the visual pathway, but rather is associated with a broader degeneration of the central nervous system.

Key Dates

First listed
Sep 3, 2026
Start date
Aug 28, 2026
Status verified
Aug 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
100 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Patient with glaucoma
    Patient with glaucoma
  • Active Comparator: Patient without glaucoma
    Patient without glaucoma

Primary Outcome Measure

structural and functional connectivity matrices [ Time Frame: Baseline ]

Central Contacts

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