Ophthalmology Clinical Trials

Recruiting ophthalmology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat ophthalmology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting ophthalmology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting ophthalmology trials

Within

Non-invasive Ultrasound Retinal Stimulation for Vision Restoration

for Age-Related Macular Degeneration

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT05914233

The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients

for Glaucoma

1 site in New Orleans

Sponsor: Tulane University

Sex: All·Age: 18+

Code: NCT04007276·Phase 4

Clinical Evaluation of a Novel Trifocal IOL

for Aphakia

Sponsor: Alcon Research

Sex: All·Age: 22+

Code: NCT07587138

A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)

for Diabetic Retinopathy

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07705607·Phase 3

Clinical Trial on the Visual Function of Enhanced Monofocal and EDoF Intraocular Lenses

for Cataract

Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Sex: All·Age: 45 - 80

Code: NCT07715071

The iD2: A Smart Eye Drop Cap Monitor for Eye Drop Adherence

for Glaucoma

Sponsor: Universal Adherence LLC

Sex: All·Age: 18+

Code: NCT07664943

Blinking Exercise Study

for Dry Eye Disease (DED)

Sponsor: St. Joseph's Healthcare Hamilton

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07554937

A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)

for Diabetic Retinopathy

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07705555·Phase 3

Clareon TruPlus vs Tecnis Eyhance IOLs in Cataract Patients

for Cataract

1 site in Gainesville

Sponsor: Gainesville Eye Associates

Sex: All·Age: 18+

Code: NCT07658040

Leveraging Artificial Intelligence to Prevent Vision Loss From Diabetes

for Diabetic Retinopathy

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 22+

Code: NCT06763952

Prospective, Randomized, Parallel-group Comparison of Two Refractive EDOF Intraocular Lenses: Johnson & Johnson Tecnis PureSee Versus 1stQ Comfort Z-EDOF

for Cataract

Sponsor: Vienna Hospital Association

Sex: All·Age: 40+

Code: NCT07688681

Glaucoma Drop Aids Part 2

for Glaucoma

1 site in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06806332

Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular Hypertension

for Glaucoma

Sponsor: SpyGlass Pharma, Inc.

Sex: All·Age: 22+

Code: NCT07641296·Phase 1

OCT-PRO Model vs. Clinicians: Cataract Surgery Outcome Prediction

for Cataract

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 18 - 90

Code: NCT07713069

Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome

for Pseudoexfoliation Syndrome

Sponsor: Kata Culina

Sex: All·Age: 50 - 85

Code: NCT07719101

Lacrifill for Ocular Surface Optimization in Cataract Surgery

for Cataract

1 site in Largo

Sponsor: The Eye Institute of West Florida

Sex: All·Age: 40+

Code: NCT07648095

Toric Performance And Constant Evaluation

for Cataract

Sponsor: Carl Zeiss Meditec AG

Sex: All·Age: 18+

Code: NCT07471295·Phase 4

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Comparison of Two Rotational Alignment Methods for Astigmatism Correction in SMILE Surgery

for Myopia

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 18 - 40

Code: NCT07696468

A Controlled Evaluation of Optical Defocus Parameters on Transient Changes in Axial Length Using Kubota Glass

for Myopia

Sponsor: Kubota Vision Inc.

Sex: All·Age: 8 - 24·Accepts healthy volunteers

Code: NCT07686289

Survey of Sensory Impairment Indicators Among Adults Aged 65 Years and Older in Xinxing County

for Visual Impairment

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07694505

Impact of Various Myopia Management Strategies on Asthenopia Among Pediatric and Adolescent Populations

for Myopia

Sponsor: Tianjin Medical University Eye Hospital

Sex: All·Age: 6 - 18

Code: NCT07691671

Know Your Pressures NYC

for Glaucoma

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT05992415

Brain Stimulation Effects on Orientation and Mobility Skills in Adults With Vision Impairment

for Retinitis Pigmentosa (RP)

Sponsor: University of Waterloo

Sex: All·Age: 18+

Code: NCT07341763

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Effects of Oxygen Cage Support During Cataract Surgery

for Cataract

Sponsor: Ataturk University

Sex: All·Age: 18 - 90

Code: NCT07632326

Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors

for Myopia

Sponsor: Sohag University

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07647146

Glaucoma Exercise as Medicine Study (GEMS).

for Glaucoma

Sponsor: Johns Hopkins University

Sex: All·Age: 21 - 80·Accepts healthy volunteers

Code: NCT05581498

Feasibility Study of a Remote Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension

for Age-Related Macular Degeneration

1 site in Los Angeles

Sponsor: Stanford University

Sex: All·Age: 55 - 75·Accepts healthy volunteers

Code: NCT07605468

GlaukomAI: Clinical Validation of an AI System for Early Glaucoma Screening

for Glaucoma

Sponsor: Fondazione G.B. Bietti, IRCCS

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07668193

Comparing Myopia Control Spectacle Lenses for Visual Comfort, Adaptation, and Satisfaction in Myopic Children

for Myopia

Sponsor: Essilor International

Sex: All·Age: 6 - 11

Code: NCT07683481

Optic Nerve Head Strain in Non-glaucoma Subjects

for Glaucoma

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 30 - 90·Accepts healthy volunteers

Code: NCT07425535·EARLY_Phase 1

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Post-refractive IOL Outcomes With Clareon TruPlus

for Cataract

1 site in Greensboro

Sponsor: Laser Defined Vision

Sex: All·Age: 18+

Code: NCT07610226

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A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy

for Diabetic Retinopathy

1 site in Glendale

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07588100·Phase 1

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Small RNA tRF-31 Changes in Patients With Age-Related Cataract

for Cataract

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 18+

Code: NCT07672899

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Strengthening Community- to- Hospital Eye Care Pathways From Boko Eye Care Center in Rural Assam

for Cataract

Sponsor: Seva Canada Society

Sex: All·Age: 18+

Code: NCT07333248

A Prospective, Randomized, Subject- and Examiner-Masked, Multicenter Study Comparing Bilateral Clareon TruPlus and Bilateral Clareon Monofocal Intraocular Lens Implantation (Spherical and Toric) in Cataract Subjects

for Cataract

1 site in Sugar Land

Sponsor: Berkeley Eye Center

Sex: All·Age: 22+

Code: NCT07693205·Phase 4

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Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery

for Cataract

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: All ages

Code: NCT07715591

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Longitudinal Measurements of Visual Diet in Children

for Myopia

1 site in New York

Sponsor: State University of New York College of Optometry

Sex: All·Age: 7 - 12·Accepts healthy volunteers

Code: NCT07642999

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Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension

for Glaucoma

1 site in Bloomington

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07588152·Phase 4

Apply to this trial

Visual and Patient Reported Outcomes With Clareon TruPlus

for Cataract

1 site in Saint Louis Park

Sponsor: OVO LASIK + Lens

Sex: All·Age: 18+

Code: NCT07648355

Apply to this trial

Inhibition of Myopia Progression With Optical Devices

for Myopia Progression

Sponsor: Semmelweis University

Sex: All·Age: 6 - 15

Code: NCT07698977

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Characterization of the Corneal Biomechanics of Patients Treated by Corneal Lenticule Extraction for Advanced Refractive Correction (CLEAR) to Correct Myopia

for Myopia

Sponsor: University of Bern

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT04817592

A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control

for Myopia

17 sites incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 5 - 11

Code: NCT07095894·Phase 3

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Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

for Diabetic Retinopathy

14 sites incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07592273·Phase 2, Phase 3

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Community-Based Eye Screening With Structured Referral Tracking for Preventing Avoidable Blindness in Adults in Rawalpindi, Pakistan

for Cataract

Sponsor: Health Services Academy, Islamabad, Pakistan

Sex: All·Age: 18+

Code: NCT07611682

A Comparative Study of the Efficacy of Myopia Control Lenses With Different Mechanisms on Controlling Myopia Progression in Patients With Intermittent Exotropia

for Intermittent Exotropia

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 6 - 12

Code: NCT07642934

Retinal Ganglion Cell Neuroprotection Under Prostaglandin Analogues

for Glaucoma

Sponsor: Association for Innovation and Biomedical Research on Light and Image

Sex: All·Age: 18+

Code: NCT07074782

Binocular and Monocular Distance-Corrected Visual Performance and Defocus Characteristics of Clareon Truplus Intraocular Lens (IOL)

for Cataract

1 site in Encino

Sponsor: Colvard Kandavel Eye Center

Sex: All·Age: 50 - 80

Code: NCT07589894

Delaying the Onset of Nearsightedness Until Treatment (DONUT) Clinical Trial

for Myopia

14 sites incl. Birmingham

Sponsor: Ohio State University

Sex: All·Age: 6 - 11·Accepts healthy volunteers

Code: NCT07567040·Phase 3

Apply to this trial

Morphometric Markers of the Effectiveness of Micropulse Cyclophotocoagulation

for Glaucoma

Sponsor: Kazakh Eye Research Institute

Sex: All·Age: 18+

Code: NCT07592923

Apply to this trial

Tear Interleukin Biomarkers After Glaucoma Treatment

for Glaucoma

Sponsor: Kazakh Eye Research Institute

Sex: All·Age: 18+

Code: NCT07592988

Apply to this trial

Rocklatan vs Latanoprost Post-DSLT

for Glaucoma

1 site in Beaumont

Sponsor: Eye Centers of Southeast Texas

Sex: All·Age: 18+

Code: NCT07465913·Phase 4

Apply to this trial

Retinal Oxygen Metabolism in Children With Myopia

for Myopia

Sponsor: Medical University of Vienna

Sex: All·Age: 8 - 13·Accepts healthy volunteers

Code: NCT07473401

Optimizing Graft Selection in Glaucoma Surgery: A Comparative Study of Sclera, Pericardium, and Corneal Tissue

for Glaucoma

Sponsor: University of Alberta

Sex: All·Age: 18 - 110

Code: NCT07285616

A Clinical Trial Assessing the Efficacy and Safety of ST-1 Silicone Hydrogel Daily Disposable Soft Contact Lenses Compared to Miru 1day UpSide

for Myopia

Sponsor: Menicon Co., Ltd.

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07345416

Artificial Intelligence-assisted Diagnosis in Ophthalmology

for Macular Degeneration

Sponsor: Marisse Masis-Solano

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07497815

Efficacy and Safety of a Releasable Intraluminal Suture Technique to Reduce Hypotony Following Glaucoma Surgery Using the Preserflo Device

for Glaucoma

Sponsor: Hôpital Privé de la Baie

Sex: All·Age: 18+

Code: NCT07531199

Evaluation of the Effectiveness of Three Tear Substitute Formulations in Postoperative Discomfort After Cataract Surgery

for Cataract

Sponsor: Democritus University of Thrace

Sex: All·Age: 45 - 85

Code: NCT07581548

Impact of a Glaucoma Awareness Program on Treatment Adherence

for Glaucoma

Sponsor: Seva Canada Society

Sex: All·Age: 18+

Code: NCT07488234

Targeted Lens Intervention for Myopic Anisometropia in Children

for Anisometropia

Sponsor: Essilor International

Sex: All·Age: 6 - 13

Code: NCT07533149

World Sight Foundation Field Machine (WSFFM) Pilot

for Glaucoma

Sponsor: Buckinghamshire Healthcare NHS Trust

Sex: All·Age: 18 - 99

Code: NCT07674069

Apply to this trial

Ophthalmology clinical trials — common questions

Are ophthalmology clinical trials free to join?

Yes. Participating in a ophthalmology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a ophthalmology clinical trial?

Each ophthalmology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a ophthalmology trial near me?

Use the location controls above. We'll show recruiting ophthalmology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many ophthalmology trials are recruiting right now?

We're currently tracking roughly 145 recruiting ophthalmology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Ophthalmology trials by city

San Francisco, CA Birmingham, AL Palo Alto, CA Boston, MA Bloomington, IN Los Angeles, CA Madison, WI Salt Lake City, UT Ann Arbor, MI Carmel, IN Chicago, IL Miami, FL

What to expect

Recruiting ophthalmology trials

Ophthalmology clinical trials — common questions

Ophthalmology trials by city

Conditions in this area