Ophthalmology Clinical Trials

Recruiting ophthalmology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat ophthalmology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting ophthalmology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting ophthalmology trials

Within

Know Your Pressures NYC

for Glaucoma

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT05992415

Non-invasive Ultrasound Retinal Stimulation for Vision Restoration

for Age-Related Macular Degeneration

Sponsor: University of Southern California

Sex: All·Age: 18+

Code: NCT05914233

Study of a Phakic Implantable Collamer Lens (ICL)

for Myopia

Sponsor: Staar Surgical Company

Sex: All·Age: 21 - 60

Code: NCT07790965

Study of an Implantable Collamer Lens (ICL)

for Myopia

Sponsor: Staar Surgical Company

Sex: All·Age: 21 - 60

Code: NCT07791381

The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients

for Glaucoma

1 site in New Orleans

Sponsor: Tulane University

Sex: All·Age: 18+

Code: NCT04007276·Phase 4

Impact of Meditation on Reducing Stress in Glaucoma Patients: An Electronic Feasibility Study

for Glaucoma

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 65+

Code: NCT07769463

Glaucoma Drop Aids Part 2

for Glaucoma

1 site in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06806332

Partial Range Of Field IOLs in DMEK-Enabled Procedures

for Cataract

Sponsor: Universitair Ziekenhuis Brussel

Sex: All·Age: 40 - 90

Code: NCT07441616

Clinical Evaluation of a Novel Trifocal IOL

for Aphakia

Sponsor: Alcon Research

Sex: All·Age: 22+

Code: NCT07587138

Baerveldt Versus Paul Study

for Glaucoma

Sponsor: University of Sydney

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07733453·Phase 4

Leveraging Artificial Intelligence to Prevent Vision Loss From Diabetes

for Diabetic Retinopathy

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 22+

Code: NCT06763952

A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)

for Diabetic Retinopathy

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07705607·Phase 3

A Prospective, Single-Arm Clinical Evaluation of Visual, Refractive, and Patient-Reported Outcomes Following Bilateral Implantation of the TECNIS PureSee™ Extended Depth of Focus Intraocular Lens

for Cataract

1 site in Sioux Falls

Sponsor: Vance Thompson Vision

Sex: All·Age: 40+

Code: NCT07790887·Phase 4

Effect of Late Ripcord Removal From Glaucoma Drainage Device

for GLAUCOMA 1, OPEN ANGLE, D (Disorder)

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07803536

Clinical Trial on the Visual Function of Enhanced Monofocal and EDoF Intraocular Lenses

for Cataract

Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Sex: All·Age: 45 - 80

Code: NCT07715071

Optimizing Graft Selection in Glaucoma Surgery: A Comparative Study of Sclera, Pericardium, and Corneal Tissue

for Glaucoma

Sponsor: University of Alberta

Sex: All·Age: 18 - 110

Code: NCT07285616

Managing Premyopia in Chinese Children Using Artificial Intelligence Assisted Defocus Incorporated Multiple Segments Based Spectacle Lens: a Randomized Controlled Clinical Trial

for Pre-myopia

Sponsor: Shanghai Eye Disease Prevention and Treatment Center

Sex: All·Age: 3 - 6

Code: NCT07765550

Exploring Perceptual Learning in Blurred Gabor Discrimination for Low-Myopic Children

for Myopia

Sponsor: National Taiwan University Hospital

Sex: All·Age: 6 - 10

Code: NCT07107646

The iD2: A Smart Eye Drop Cap Monitor for Eye Drop Adherence

for Glaucoma

Sponsor: Universal Adherence LLC

Sex: All·Age: 18+

Code: NCT07664943

Contact Lenses to Slow Myopia Progression in Adults

for Myopia

1 site in Berkeley

Sponsor: University of California, Berkeley

Sex: All·Age: 18 - 30

Code: NCT07747311

Blinking Exercise Study

for Dry Eye Disease (DED)

Sponsor: St. Joseph's Healthcare Hamilton

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07554937

Evaluation of Orthokeratology Lenses With a 5MM Optic Zone Diameter

for Myopia

2 sites incl. Pleasanton

Sponsor: CooperVision International Limited (CVIL)

Sex: All·Age: 7 - 35

Code: NCT07751172

A Study About the Safety of ASP2767 and Whether it Helps People With Glaucoma-Related Optic Nerve Damage

for Glaucoma

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07770685·Phase 1, Phase 2

Validation of the Vision Trainer Clinical Decision-Support Software

for Myopia

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07773753

A Pilot Evaluation of Refractive Error Progression in Pre-Myopic Children in Singapore With and Without Myopia Control Spectacles

for Myopia

Sponsor: Singapore National Eye Centre

Sex: All·Age: 6 - 12·Accepts healthy volunteers

Code: NCT07779941

Night Driving After Trifocal Versus Monofocal IOL Implantation

for Cataract

Sponsor: Jin Yang

Sex: All·Age: 18 - 85

Code: NCT07755189

Magnetic Resonance Imaging of Cerebral Connectivity and Volume in Neurodegeneration and Glaucoma

for Glaucoma

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT07802769

Apply to this trial

A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)

for Diabetic Retinopathy

3 sites incl. Glendale

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07705555·Phase 3

Apply to this trial

Effectiveness of Digital Defocus Vision Training With Low-Concentration Atropine on the Prevention and Control of Myopia in Children: A Clinical Study

for Myopia

Sponsor: Beijing Tongren Hospital

Sex: All·Age: 6 - 12·Accepts healthy volunteers

Code: NCT07724210

AI-Driven IOL Prediction Using SS-OCT Biometry

for Cataract

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 18+

Code: NCT07733154

The Rebound Effect on Repeated Low-Level Red Light Therapy for Myopia

for Myopia

Sponsor: The First Affiliated Hospital of Anhui Medical University

Sex: All·Age: 8 - 16

Code: NCT07748546

VividFlo System Validation Study

for Glaucoma

Sponsor: VividWhite Pty Ltd

Sex: All·Age: 18+

Code: NCT07754201

SMILE Surgery in One Eye Compared to Ray Tracing-guided LASIK Surgery in the Fellow Eye

for Myopia

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 22 - 59

Code: NCT07721714·Phase 4

Apply to this trial

Dietary Supplement for Myopia Control

for Myopia

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 8 - 13

Code: NCT07406906

Prospective, Randomized, Parallel-group Comparison of Two Refractive EDOF Intraocular Lenses: Johnson & Johnson Tecnis PureSee Versus 1stQ Comfort Z-EDOF

for Cataract

Sponsor: Vienna Hospital Association

Sex: All·Age: 40+

Code: NCT07688681

The Effectiveness Of Home-Based Circuit Training On Eye Pressure And Eye Nerve Structures In Patients With Glaucoma

for Glaucoma

Sponsor: Universiti Sains Malaysia

Sex: All·Age: 18 - 70

Code: NCT07733388

Innovative Tube Trabeculectomy for Advanced and Refractory Glaucoma: A Randomized Controlled Trial

for Glaucoma

Sponsor: Benha University

Sex: All·Age: 18+

Code: NCT07755761

Apply to this trial

Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular Hypertension

for Glaucoma

Sponsor: SpyGlass Pharma, Inc.

Sex: All·Age: 22+

Code: NCT07641296·Phase 1

Lacrifill for Ocular Surface Optimization in Cataract Surgery

for Cataract

1 site in Largo

Sponsor: The Eye Institute of West Florida

Sex: All·Age: 40+

Code: NCT07648095

Apply to this trial

Clareon TruPlus vs Tecnis Eyhance IOLs in Cataract Patients

for Cataract

1 site in Gainesville

Sponsor: Gainesville Eye Associates

Sex: All·Age: 18+

Code: NCT07658040

Apply to this trial

OCT-PRO Model vs. Clinicians: Cataract Surgery Outcome Prediction

for Cataract

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 18 - 90

Code: NCT07713069

Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome

for Pseudoexfoliation Syndrome

Sponsor: Kata Culina

Sex: All·Age: 50 - 85

Code: NCT07719101

Corneal Biomechanics and Surgically Induced Astigmatism in Pseudoexfoliation Syndrome

for Pseudoexfoliation Syndrome

Sponsor: Kata Culina

Sex: All·Age: 50 - 85

Code: NCT07722247

Apply to this trial

Toric Performance And Constant Evaluation

for Cataract

Sponsor: Carl Zeiss Meditec AG

Sex: All·Age: 18+

Code: NCT07471295·Phase 4

Apply to this trial

Comparison of Two Rotational Alignment Methods for Astigmatism Correction in SMILE Surgery

for Myopia

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 18 - 40

Code: NCT07696468

A Controlled Evaluation of Optical Defocus Parameters on Transient Changes in Axial Length Using Kubota Glass

for Myopia

Sponsor: Kubota Vision Inc.

Sex: All·Age: 8 - 24·Accepts healthy volunteers

Code: NCT07686289

Survey of Sensory Impairment Indicators Among Adults Aged 65 Years and Older in Xinxing County

for Visual Impairment

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07694505

Impact of Various Myopia Management Strategies on Asthenopia Among Pediatric and Adolescent Populations

for Myopia

Sponsor: Tianjin Medical University Eye Hospital

Sex: All·Age: 6 - 18

Code: NCT07691671

Assessing the Impact of Streetscape Exposure on Children's Perception

for Myopia

Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Sex: All·Age: 6 - 18·Accepts healthy volunteers

Code: NCT07761949

Apply to this trial

Brain Stimulation Effects on Orientation and Mobility Skills in Adults With Vision Impairment

for Retinitis Pigmentosa (RP)

Sponsor: University of Waterloo

Sex: All·Age: 18+

Code: NCT07341763

Apply to this trial

Effects of Oxygen Cage Support During Cataract Surgery

for Cataract

Sponsor: Ataturk University

Sex: All·Age: 18 - 90

Code: NCT07632326

Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors

for Myopia

Sponsor: Sohag University

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07647146

Cross-modal Neuromodulation to Improve Balance and Cognition in Older Adults With Glaucoma: A Randomized Trial of Cerebellar Transcranial Electrical Stimulation

for Glaucoma

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 55+

Code: NCT07771699

Apply to this trial

Feasibility Study of a Remote Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension

for Age-Related Macular Degeneration

1 site in Los Angeles

Sponsor: Stanford University

Sex: All·Age: 55 - 75·Accepts healthy volunteers

Code: NCT07605468

GlaukomAI: Clinical Validation of an AI System for Early Glaucoma Screening

for Glaucoma

Sponsor: Fondazione G.B. Bietti, IRCCS

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07668193

Comparing Myopia Control Spectacle Lenses for Visual Comfort, Adaptation, and Satisfaction in Myopic Children

for Myopia

Sponsor: Essilor International

Sex: All·Age: 6 - 11

Code: NCT07683481

Post-refractive IOL Outcomes With Clareon TruPlus

for Cataract

1 site in Greensboro

Sponsor: Laser Defined Vision

Sex: All·Age: 18+

Code: NCT07610226

Apply to this trial

Optic Nerve Head Strain in Non-glaucoma Subjects

for Glaucoma

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 30 - 90·Accepts healthy volunteers

Code: NCT07425535·EARLY_Phase 1

Apply to this trial

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy

for Diabetic Retinopathy

1 site in Glendale

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07588100·Phase 1

Apply to this trial

Small RNA tRF-31 Changes in Patients With Age-Related Cataract

for Cataract

Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine

Sex: All·Age: 18+

Code: NCT07672899

Apply to this trial

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Ophthalmology clinical trials — common questions

Are ophthalmology clinical trials free to join?

Yes. Participating in a ophthalmology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a ophthalmology clinical trial?

Each ophthalmology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a ophthalmology trial near me?

Use the location controls above. We'll show recruiting ophthalmology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many ophthalmology trials are recruiting right now?

We're currently tracking roughly 145 recruiting ophthalmology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Ophthalmology trials by city

Palo Alto, CA San Francisco, CA Birmingham, AL Boston, MA Bloomington, IN Los Angeles, CA Madison, WI Salt Lake City, UT Ann Arbor, MI Carmel, IN Glendale, CA Miami, FL

What to expect

Recruiting ophthalmology trials

New trials in Palo Alto, CA?

Ophthalmology clinical trials — common questions

Ophthalmology trials by city

Conditions in this area