Frailty, Immunonutrition, Surgery Type, and Biologic Recovery in Elderly Gastric Cancer

Sponsor
Kocaeli City Hospital
Study ID
NCT07803159
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Laparoscopic Gastrectomy — PROCEDURE
    Elective radical gastrectomy performed using a laparoscopic approach as part of routine clinical care. The surgical approach is not assigned by the study
  • Open Gastrectomy — PROCEDURE
    Elective radical gastrectomy performed using an open approach as part of routine clinical care. The surgical approach is not assigned by the study

Study Details

This prospective observational cohort study will evaluate the effects of multidimensional frailty phenotypes, immunonutritional status, and surgical approach on biological recovery in patients aged 60 years and older undergoing surgery for gastric cancer. Preoperative assessment will include physical and cognitive frailty, nutritional status, handgrip strength, and skeletal muscle characteristics on computed tomography. Patients will be followed prospectively during the perioperative period, including assessment of inflammatory markers, postoperative complications, delirium, hospital length of stay, and functional recovery. The study aims to determine whether multidimensional frailty and immunonutritional factors are associated with postoperative outcomes and whether surgical approach influences biological recovery in older patients with gastric cancer. A total of 328 patients are planned to be included at Kocaeli City Hospital.

Key Dates

First listed
Sep 3, 2026
Start date
Sep 30, 2026
Status verified
Aug 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
328 participants (estimated)

Arms

  • Arm: Laparoscopic Surgery
    Patients undergoing elective radical gastrectomy through a laparoscopic approach. The surgical approach is determined by routine clinical practice and is not assigned by the study.
  • Arm: Open Surgery
    Patients undergoing elective radical gastrectomy through an open approach. The surgical approach is determined by routine clinical practice and is not assigned by the study.

Primary Outcome Measure

Rate of postoperative complication [ Time Frame: Up to 30 days post-operative ]

Central Contacts

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