Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Shirley Ryan AbilityLab
Study ID
NCT07814313
Status
Recruiting
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Conditions

  • Healthy Control
  • Spinal Cord Injury

Eligibility Criteria

Sex
ALL
Age
19 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • CST PAS — OTHER
    transcranial magnetic stimulation and peripheral nerve stimulation are given at almost the same time to target brain-to-spinal cord connections
  • RST PAS — OTHER
    transcranial magnetic stimulation and peripheral nerve stimulation are given at almost the same time to target brainstem-to-spinal cord connections
  • sham PAS — OTHER
    the setup will look and feel the same to the participant as the CST PAS or RST PAS. But one or both of the stimulations is not actually delivered, or it is delivered in a way that does not affect the participant

Study Details

This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control. The study includes two experiments. Experiment 1 will assess corticospinal and reticulospinal tract transmission to lower-limb muscles in older adults with and without SCI. Experiment 2 will examine how aging and spinal cord injury affect the body's ability to strengthen nerve pathways involved in movement. The investigators will compare two pathways that help control leg movement, the corticospinal and reticulospinal pathways, to determine whether aging affects these pathways differently and whether spinal cord injury has a greater effect on the corticospinal pathway.

Key Dates

First listed
Sep 10, 2026
Start date
Aug 28, 2025
Status verified
Sep 2026
Primary completion
Sep 30, 2030
Completion
Sep 30, 2031

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: healthy control
  • Arm: spinal cord injury

Primary Outcome Measure

Motor evokoed potential [ Time Frame: Periprocedural ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Shirley Ryan AbilitylabChicagoIllinois60611
Monica Perez
[email protected]
312-238-2886

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Shirley Ryan Abilitylab· Chicago, IL

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