Effects of Pistachios on Postprandial Metabolic Responses in Adults With Overweight or Obesity

Conditions

• Obesity / Overweight

Eligibility Criteria

Sex

ALL

Age

18 Years - 35 Years

Healthy Volunteers

Not accepted

Interventions

• Pistachio Co-consumption — OTHER
  Participants will consume 30 g of shelled, lightly salted pistachios together with a standardized high-glycemic breakfast meal. The pistachios and standardized breakfast meal will be consumed within a fixed 10-minute meal period.
• Refined-Carbohydrate Control Co-consumption — OTHER
  Participants will consume an isocaloric refined-carbohydrate control food together with the same standardized high-glycemic breakfast meal. The control food will be matched to the pistachio condition for energy content as closely as possible while providing minimal fiber, protein, unsaturated fat, and bioactive compounds.

Study Details

This randomized controlled crossover study will examine the acute effects of pistachio consumption on postprandial metabolic responses in adults with overweight or obesity. Participants will complete two experimental conditions in randomized order. In one condition, participants will consume 30 g of pistachios with a standardized meal, and in the other condition they will receive an isocaloric refined-carbohydrate control condition with the standardized meal. The study will evaluate postprandial insulin and glucose responses over approximately 3 hours after meal consumption. Additional outcomes will include continuous glucose monitoring measures, blood lipid responses, appetite and satiety ratings, and exploratory measures related to insulin sensitivity and gastrointestinal hormone responses. The study is designed to determine whether pistachio consumption alters acute metabolic responses compared with an isocaloric refined-carbohydrate control in adults with overweight or obesity.

Key Dates

First listed

Oct 2, 2026

Start date

Oct 31, 2026

Status verified

Sep 2026

Primary completion

Jul 31, 2027

Completion

Jul 31, 2027

Study Design

Enrollment

28 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Pistachio Then Control Sequence
  Participants randomized to this sequence will first complete the pistachio condition, in which 30 g of shelled pistachios are consumed with the standardized high-glycemic breakfast meal. After a 3-7 day washout period, participants will complete the refined-carbohydrate control condition, in which an isocaloric refined-carbohydrate control food is consumed with the same standardized breakfast meal.
• Experimental: Control Then Pistachio Sequence
  Participants randomized to this sequence will first complete the refined-carbohydrate control condition, in which an isocaloric refined-carbohydrate control food is consumed with the standardized high-glycemic breakfast meal. After a 3-7 day washout period, participants will complete the pistachio condition, in which 30 g of shelled pistachios are consumed with the same standardized breakfast meal.

Primary Outcome Measure

Postprandial Insulin Incremental Area Under the Curve (iAUC) [ Time Frame: 0-180 minutes after meal consumption ]

Central Contacts

• Hossein Rafiei, PhD, RD
  314-977-8675
  [email protected]

Locations (1)

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