Study to Evaluate the Effects of Oral Glyceryl Guiacolate (Guaifenesin, GGE) on Sputum Rheology in Subjects With Mucus Hypersecretion

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT07873632
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Bronchitis
  • Bronchitis, Chronic

Eligibility Criteria

Sex
ALL
Age
40 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Glycerol Guiacolate — DRUG
    Participants will receive 28 days (+3 days for flexible scheduling) dosing of Glycerol Guiacolate (GGE) (2 x 600 mg for a total of 1200mg) taken twice daily (total of 2400 mg) in addition to current medications.
  • SOC (Standard of care) — DRUG
    Current medication excluding mucolytics or steroids

Study Details

A Randomized, Dosing vs Standard of Care, Single-Center, Multiple Dose Study to Evaluate the Effects of Oral Glyceryl Guiacolate (Guaifenesin, GGE) on Sputum Rheology in Subjects With Mucus Hypersecretion

Key Dates

First listed
Oct 14, 2026
Start date
Oct 31, 2026
Status verified
Sep 2026
Primary completion
Dec 31, 2027
Completion
Mar 31, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Glycerol Guiacolate
    Glycerol Guiacolate (Mucinex) Extended release 2 x 600 mg tablets bis in die (BID)
  • Other: Standard of Care
    Current medication Participant is currently using

Primary Outcome Measure

Change in mucus viscosity [ Time Frame: Baseline to end of treatment (Day 28) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Marsico Lung InstituteChapel HillNorth Carolina27599
Wayne Anderson, MEd, PhD
[email protected]
9197498526
Carole Robinette, MS, CPFT, ACSM:CEP
[email protected]

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By research site
Marsico Lung Institute· Chapel Hill, NC

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