Mood disorders Clinical Trials

Recruiting mood disorders studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat mood disorders. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting mood disorders studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting mood disorders trials

Within

Whole-Body Hyperthermia for Mood and Anxiety Disorders

for Postpartum Depression

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06144294

MyFILM: A Pilot Study for Social-Emotional Learning in Clinical Youth

for Mood Disorders

Sponsor: Mark Sinyor

Sex: All·Age: 9 - 12

Code: NCT07708168

Phase II: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings

for Anxiety

2 sites incl. Monterey

Sponsor: Stanford University

Sex: All·Age: 5 - 14

Code: NCT07155707

Apply to this trial

Evaluation of a Dietary Supplement Containing Melissa Officinalis Formulated in Phospholipids on Mood Well-being and Cortisol Modulation

for Stress

Sponsor: Azienda di Servizi alla Persona di Pavia

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06942897

Light and Sleep Fragmentation

for Sleep

1 site in Redwood City

Sponsor: Stanford University

Sex: All·Age: 65 - 99·Accepts healthy volunteers

Code: NCT06009289·Phase 4

Psychobiological Markers to Improve Diagnosis and to Predict Affective Episodes in Bipolar Disorder

for Major Depressive Disorder

Sponsor: Karolinska Institutet

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07427966

Investigation on Suicide Risk Factors of Patients With Mood Disorders

for Mood Disorders

Sponsor: Tianjin Anding Hospital

Sex: All·Age: 16 - 60

Code: NCT07523490

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Imagery Rescripting in Primary Care

for Major Depressive Diorder

Sponsor: University of Amsterdam

Sex: All·Age: 18 - 70

Code: NCT07362511

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Unified Protocol in Penitentiary Facilities

for Depression Disorders

Sponsor: Instituto de Investigación Sanitaria Aragón

Sex: All·Age: 18+

Code: NCT07070531

Youth Suicide Risk Factors, Reduction of Suicide Risk Factor in Youth People

for Mood Disorders

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18 - 25·Accepts healthy volunteers

Code: NCT07188506

Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT

for Multimorbidity

Sponsor: KU Leuven

Sex: All·Age: 65+

Code: NCT07211750

Apply to this trial

Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course

for Depression - Major Depressive Disorder

Sponsor: University of Windsor

Sex: All·Age: 18+

Code: NCT07088939

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Psychiatric Disorders in Child and Adolescent Offspring of Parents with Schizophrenia and Bipolar Disorders.

for Mood Disorders

Sponsor: Assiut University

Sex: All·Age: 6 - 18

Code: NCT06874075

Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults

for Intrinsic Capacity

Sponsor: University of Sao Paulo

Sex: All·Age: 60+

Code: NCT06968702

Neurofilament Light Chain Correlation With Severity of Symptoms and Cognitive Decline in Mood Disorders

for Mood Disorders

Sponsor: Assiut University

Sex: All·Age: 15 - 50

Code: NCT06877442

Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression

for Late Life Depression (LLD)

Sponsor: Centre for Addiction and Mental Health

Sex: All·Age: 60+

Code: NCT06854367

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Digital Phenotypes for Predicting Depression

for Depression - Major Depressive Disorder

Sponsor: Korea University Anam Hospital

Sex: All·Age: 19 - 75·Accepts healthy volunteers

Code: NCT07151846

7T Amygdala and Citalopram Study

for Emotional Processing

Sponsor: University of Oxford

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06412315

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A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences

for Psychotic Disorders

1 site in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 30

Code: NCT06929442

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Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

for Major Depressive Disorder

1 site in Sunnyvale

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06376734·Phase 2

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Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

for Suicide

1 site in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70

Code: NCT06511908·Phase 2

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I-CARE: A Pilot Study of Cognitive Behavioural Therapy(CBT) for Mood and Anxiety Disorders

for Mood Disorders

Sponsor: Sunnybrook Health Sciences Centre

Sex: All·Age: 14 - 19

Code: NCT06532500

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A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Motor and Non-Motor Symptoms in Parkinson's Disease

for Parkinson Disease

Sponsor: Anhui Medical University

Sex: All·Age: 40 - 80

Code: NCT06642454

Suicide Specific Rumination in Veterans

for Depression

1 site in The Bronx

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65

Code: NCT06481033

Apply to this trial

Neuro-computational Study of Thymic Fluctuations in Mood Disorders

for Depression

Sponsor: Centre Hospitalier St Anne

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07033923

Apply to this trial

Cold and Heat Investigation to Lower Levels of Depression

for Depression

1 site in Edwards

Sponsor: Barry Sandler

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06263738

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Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device

for ADHD

1 site in Philadelphia

Sponsor: Gaize

Sex: All·Age: 18 - 65

Code: NCT07389473

Apply to this trial

Sensory Profile and Early Clinical Signs of Calm Room Users

for Psychotic Disorders

Sponsor: Centre Hospitalier Esquirol

Sex: All·Age: 18 - 65

Code: NCT06839950

Apply to this trial

An Innovative Master Platform for Clinical Trials in Mood Disorders

for Mood Disorders

Sponsor: St. Joseph's Healthcare Hamilton

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT06408012

Apply to this trial

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

for Insulin Resistance

2 sites incl. Aurora

Sponsor: Colorado State University

Sex: Female·Age: 12 - 17·Accepts healthy volunteers

Code: NCT05543083

Apply to this trial

Neurostimulation Versus Therapy for Problems With Emotions

for Emotion Regulation

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 55

Code: NCT05712057

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Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders

for Mood Disorders

1 site in Syracuse

Sponsor: Parnassia Groep

Sex: All·Age: 16 - 70

Code: NCT05656469

Apply to this trial

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

for Mood Disorders

3 sites incl. Monroeville

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 100

Code: NCT05658796

Apply to this trial

Big Feelings: A Study on Children's Emotions in Therapy

for Anxiety Disorders

Sponsor: University of Guelph

Sex: All·Age: 8 - 15

Code: NCT05637320

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Evaluation of Mood Disorders Under Biologics in Chronic Inflammatory Rheumatic Disease

for Rheumatic Diseases

Sponsor: Centre Hospitalier Universitaire de Besancon

Sex: All·Age: 18 - 80

Code: NCT04817072

Apply to this trial

Mindful Yoga for Postpartum Depression

for Mood Disorders

Sponsor: The Hong Kong Polytechnic University

Sex: Female·Age: 18 - 60

Code: NCT06275217

Apply to this trial

Mechanisms of Rumination Change in Adolescent Depression

for Major Depressive Disorder

3 sites incl. Columbus

Sponsor: Ohio State University

Sex: All·Age: 14 - 17

Code: NCT03859297

Apply to this trial

Nitrous Oxide- Suicidal Ideation

for Major Depressive Disorder

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 65

Code: NCT03736538·Phase 1

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

for Mood Disorders

1 site in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT00397111

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Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

for Mood Disorders

1 site in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 3 - 99·Accepts healthy volunteers

Code: NCT00024635

Apply to this trial

Mood disorders clinical trials — common questions

Are mood disorders clinical trials free to join?

Yes. Participating in a mood disorders clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a mood disorders clinical trial?

Each mood disorders study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a mood disorders trial near me?

Use the location controls above. We'll show recruiting mood disorders trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many mood disorders trials are recruiting right now?

We're currently tracking roughly 20 recruiting mood disorders trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Mood disorders trials by city

Aurora, CO Columbus, OH Redwood City, CA

Related specialties

Psychiatry Mental health