Oncology Clinical Trials in Charleston, SC

As of August 2026, 103 paid clinical trials are recruiting for Oncology in Charleston, South Carolina. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 31, 2026.

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105 clinical trials for Oncology

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Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

for Biochemically Recurrent Prostate Carcinoma

Drug: Apalutamide

Sites in Charleston +277 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: Male·Age: 18+

Code: NCT04423211·Phase 3·Recruiting·Listed Jun 2020

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Charleston, Bluffton +479 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

Sites in Charleston, Beaufort +372 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024

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MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

Sites in Charleston, Boiling Springs +328 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting·Listed Oct 2022

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Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

Sites in Charleston, Greenwood +278 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting·Listed Apr 2022

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Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Sites in Charleston, Boiling Springs +228 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 60+

Code: NCT05976763·Phase 3·Recruiting·Listed Aug 2023

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Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Sites in Charleston, Boiling Springs +204 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554406·Phase 2·Recruiting·Listed Sep 2022

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Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Charleston, Boiling Springs +214 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06317649·Phase 2·Recruiting·Listed Mar 2024

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in Charleston, Columbia +189 more locations

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024

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Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

Sites in Charleston, Columbia +185 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting·Listed May 2019

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A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

Sites in Charleston, Columbia +167 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020

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Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

Sites in Charleston, Columbia +225 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting·Listed Mar 2015

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

Sites in Charleston, Columbia +154 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Charleston, Columbia +200 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

Sites in Charleston, Columbia +152 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Charleston, Columbia +141 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

Sites in Charleston +20 more locations

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting·Listed May 2019

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Charleston +112 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

for Neuroblastoma

Sites in Charleston +19 more locations

Sponsor: Giselle Sholler

Sex: All·Age: 12 Months - 21

Code: NCT05489887·Phase 2·Recruiting·Listed Aug 2022

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Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for Malignant Solid Neoplasm

Sites in Charleston, Hilton Head Island +586 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04871542·Recruiting·Listed May 2021

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Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

for Hematopoietic and Lymphatic System Neoplasm

Sites in Charleston, Anderson +26 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06279013·Recruiting·Listed Feb 2024

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Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

for Locoregional Recurrence

Drug: Ribociclib

Sites in Charleston +18 more locations

Sponsor: Oana Danciu

Sex: All·Age: 18+

Code: NCT05467891·Phase 2·Recruiting·Listed Jul 2022

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Hypofractionated Radiotherapy With a Focal Microboost for High-Risk and Locally Advanced Prostate Cancer

for Prostate Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: Male·Age: 18+

Code: NCT07325721·Phase 2·Recruiting·Listed Jan 2026

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

Sites in Charleston, Spartanburg +39 more locations

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting·Listed Feb 2022

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Health Education Approach to Lung Screening

for Lung Cancer

Sites in Charleston +2 more locations

Sponsor: Virginia Commonwealth University

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT06070870·Recruiting·Listed Oct 2023

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

for Lung Non-Small Cell Carcinoma

Sites in Charleston +242 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06116682·Phase 2·Recruiting·Listed Nov 2023

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Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

Sites in Charleston +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting·Listed Dec 2023

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Optimizing Care for Cancer Survivors With Depression: Project 3

for Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06930729·Recruiting·Listed Apr 2025

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Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

Sites in Charleston, Beaufort +462 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting·Listed May 2024

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Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

for Relapsed or Refractory Acute Myeloid Leukemia (AML)

Sites in Charleston +2 more locations

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT02074839·Phase 1·Recruiting·Listed Feb 2014

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International Registry for Men With Advanced Prostate Cancer (IRONMAN)

for Prostate Cancer

Sites in Charleston +34 more locations

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 21+

Code: NCT03151629·Recruiting·Listed May 2017

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Prediction Augmented Screening Initiative

for Lung Cancer

Sites in Charleston +3 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 50 - 80

Code: NCT06538636·Recruiting·Listed Aug 2024

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CBD for Breast Cancer Primary Tumors

for Breast Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06148038·Phase 1·Recruiting·Listed Nov 2023

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Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

for Neuroblastoma

Sites in Charleston +19 more locations

Sponsor: Giselle Sholler

Sex: All·Age: Up to 22

Code: NCT02559778·Phase 2·Recruiting·Listed Sep 2015

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The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

for Head and Neck Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05811936·Recruiting·Listed Apr 2023

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Evaluating the Communication Between Patients and Providers in Cancer Clinics

for Cancer

Sites in Charleston +2 more locations

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT06985953·Recruiting·Listed May 2025

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IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06582784·Recruiting·Listed Sep 2024

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Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

for Brain Metastases

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07227610·Phase 2·Recruiting·Listed Nov 2025

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Charleston +14 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

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COAST Therapy in Advanced Solid Tumors and Prostate Cancer

for Prostate Cancer Recurrent

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05036226·Phase 1, Phase 2·Recruiting·Listed Sep 2021

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Conditions in Oncology (Charleston, SC)

Non-small cell lung cancer (NSCLC)· 14 Breast cancer· 11 Solid tumor· 11 Acute myeloid leukemia (AML)· 8 Cancer (any)· 8 Prostate cancer· 7 Myelodysplastic syndromes (MDS)· 7 Head and neck cancer· 7 Ovarian cancer· 6 Multiple myeloma· 5 Lung cancer· 4 Esophageal cancer· 4 Neuroblastoma· 4 Triple-negative breast cancer· 3 Colorectal cancer· 3 Metastatic prostate cancer· 3 Bladder cancer· 3 Endometrial cancer· 3 Leukemia (other)· 3 Non-Hodgkin lymphoma· 3 Hematologic malignancy· 3 Pancreatic cancer· 2 Gastric cancer· 2 Kidney cancer· 2 Cervical cancer· 2 Chronic lymphocytic leukemia (CLL)· 2 Chronic myelomonocytic leukemia· 2 Myelofibrosis· 2 Diffuse large B-cell lymphoma (DLBCL)· 2 Osteosarcoma· 2 HER2-negative breast cancer· 1 Small cell lung cancer· 1 Gastroesophageal junction cancer· 1 Fallopian tube cancer· 1 Glioblastoma· 1 Brain cancer· 1 Brain metastases· 1 Acute lymphoblastic leukemia· 1 Myeloproliferative neoplasm· 1 Hodgkin lymphoma· 1 Mantle cell lymphoma· 1 Small lymphocytic lymphoma· 1 Melanoma· 1 Skin cancer· 1 Thyroid cancer· 1 Sarcoma· 1 Soft tissue sarcoma· 1 Pediatric cancer· 1